« Home « Kết quả tìm kiếm

Quinoline derivatives

Tìm thấy 12+ kết quả cho từ khóa "Quinoline derivatives"

NGHIÊN CỨU TỔNG HỢP MỘT SỐ DẪN XUẤT MỚI QUINOLINE CHỨA NHÂN PYRAZOLE Synthesis of novel pyrazole-based quinoline derivatives

www.academia.edu

NGHIÊN CỨU TỔNG HỢP MỘT SỐ DẪN XUẤT MỚI QUINOLINE CHỨA NHÂN PYRAZOLE Synthesis of novel pyrazole-based quinoline derivatives Đào Huy Toàn, Lê Thị Thùy, Vũ Đình Hoàng, Hoàng Xuân Tiến, Trần Khắc Vũ Bộ môn Công nghệ Hóa dược & Hóa chất bảo vệ thực vật- Khoa công nghệ Hóa học- Trường Đại học Bách khoa Hà Nội Số 1- Đại Cồ Việt, Hai Bà Trưng, Hà Nội E-mail: [email protected] Abstract Novel pyrazole-based quinoline derivatives (7a-b) were synthesized in good yields by a three-step procedure.

Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities

tailieu.vn

In addition, because many quinoline derivatives demonstrate impressive anticancer activities, 11 − 14 we studied the anticancer activities of the 6,8- disubstitued quinoline derivatives against several tumor cell lines. In the first step, dibromide 2 was treated with MeONa in the presence of CuI in boiling DMF to give a mixture of methoxyquinolines 3 and 4, and the proportion of the products depended on the reaction time.

Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents

tailieu.vn

However, in this work, a new and practical method was used for the synthesis of substituted quinoline derivatives.

Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

tailieu.vn

In the literature, there are various examples of quinoline-based triazole compounds derived from 8-(prop-2- ynyloxy)quinoline 1, 2, and 5, which have been used as fluorescence metal sensors and antibacterial agents. 21 − 29 Propargyl-substituted quinoline derivatives 1–9 were synthesized by O-propargylation method with the addition of propargyl bromide in the presence of K 2 CO 3 to commercially available 2-substituted 8- hydroxyquinoline derivatives (Scheme)..

Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors

tailieu.vn

Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs).

Advances in polymer based Friedlander quinoline synthesis

tailieu.vn

Amberlyst-15-catalyzed novel synthesis of quinoline derivatives in ionic liquid. Dowex-50W promoted Friedländer synthesis of substituted quinolines under solvent- free conditions. PEG-SO 3 H as a catalyst in aqueous media: A simple, proficient and green approach for the synthesis of quinoline derivatives. Synthesis of tacrine derivatives under solventless conditions.

An efficient one-pot, three-component synthesis of 6-cyano-hexahydro-4H-thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives from β-enaminones

tailieu.vn

In conjunction with our ongoing research work on enamines 20 − 30 and spiro-heterocyclic compounds, 25,27,30 we report herein the synthesis of hexahydro-4H -thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives via the Michael addition reaction of the cyclic β -enaminone with α, β -unsaturated nitrile derivatives. Synthesis of thieno[3’,2’:5,6]pyrimido[1,2-a ]quinoline derivatives 5a–d..

Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction

tailieu.vn

The exceptionally high anticancer activity of PEGylated quinoline derivatives is suggestive of the fact that the enhanced efficacy of molecules maybe because of the high mobility of the end terminal of the tethered PEG molecules, and due to the presence of inter-repulsive forces exerted between the hydrated PEG chains. However, the imine derivatives of the PEGylated quinoline did Table 9. Water solubility evaluation of the synthesized compounds..

TỔNG HỢP CÁC DẪN XUẤT MỚI QUINOLINE CHỨA MẠCH NHÁNH CHALCONE

www.academia.edu

THÁNG 8 NĂM 2011 TỔNG HỢP CÁC DẪN XUẤT MỚI QUINOLINE CHỨA MẠCH NHÁNH CHALCONE Lê Thị Thuỳ, Đào Huy Toàn, Hoàng Xuân Tiến, Trần Khắc Vũ Bộ môn Công nghệ Hoá dược & Hoá chất bảo vệ thực vật, Viện Kỹ thuật Hóa học Trường Đại học Bách khoa Hà Nội Đến Tòa soạn 14-7-2010 Abstract Novel chalcone-based quinoline derivatives (7a-c) were synthesized via a two-step procedure.

Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates

tailieu.vn

Terminal acetylenes on quinoline derivatives 1–3 make them valuable candidates for one-pot synthesis of the target triazole structures.

Tổng hợp dẫn xuất 8-hydroxyquinoline-6-carboxamide

ctujsvn.ctu.edu.vn

Motasim Billah et al., 2002, Pharmacology of N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8- methoxy-2-(trifluoromethyl)-5-quinoline Carboxamide (SCH 351591), a Novel, Orally Active Phosphodiesterase 4. Normand-Bayle et al., 2005, New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity, Bioorg. Savini et al., 2001, Synthesis and. Vlahov et al., 1990, Synthesis of some new quinoline derivatives – potential

Design, synthesis, and antitumor evaluation of novel methylene moiety-tethered tetrahydroquinoline derivatives

tailieu.vn

As part of our ongoing work on quinoline chemistry, we herein report a new approach for the synthesis of new methylene-tethered THQs and cyclopenta[ b ]pyridines to explore their cytotoxic effects on rat glioblastoma (C6), human breast cancer (MCF-7), prostate cancer (PC3), neuroblastoma (SH-SY5Y), and mouse fibroblast (L929) cell lines..

Recent synthetic methodologies for pyrimidine and its derivatives

tailieu.vn

Preparation of quinoline based pyrimidine derivatives 82.. Ibrahim and El-Metwally synthesized pyrimidine derivatives by the treatment of acetoacetanilides 83, 2,4-dihydroxy benzaldehyde 84, and thiourea 58 in the presence of ethanol and conc. Benzylation of pyrimidine 85 followed by oxidation or reaction with primary amines afforded pyrimidine derivatives 87 and 88, respectively (Scheme 21).

Khóa luận tốt nghiệp: Dị vòng quinoline, Acid 2-methylquinoline-4-carboxylic, Acid quinoline-4-carboxylic

tailieu.vn

Người thực hiện: SV Đặng Thùy Trinh Trang 6 D ựa theo phương pháp này, nhiều dẫn xuất của acid quinoline-4-carboxylic không có ho ặc có nhóm thế trong vòng benzene đã được tổng hợp và chuyển hóa tiếp theo t ạo thành các hợp chất giống quinoline về mặt cấu trúc và nghiên cứu ứng dụng trong hóa dược..

Investigation of the structural and physicochemical requirements of quinoline-arylamidine hybrids for the growth inhibition of K562 and Raji leukemia cells

tailieu.vn

Our results are consistent with the previous results of a docking study of azaacridine derivatives, 27 which revealed that the amido moiety formed two hydrogen bonds with Glu-310 and Asp-404 in the DFG out-pocket of c-SRC. 28) between quinoline and arylamidine enhanced anticancer activity compared to the other compounds (1–14) without an amino group in the central linker..

Synthesis and photochromism of new asymmetrical diarylethenes with a variable heteroaryl ring and a quinoline unit

tailieu.vn

Addition of trifluoroacetic acid to solution of the diarylethenes produced protonated derivatives with notable changes in their absorption spectra. These results indicated that the effect of the heteroaryl rings played a very important role during the process of photoisomerization for these diarylethene derivatives..

Antioxidant properties of water-soluble phthalocyanines containing quinoline 5-sulfonic acid groups

tailieu.vn

Abstract: In the present study, the antioxidant properties of peripherally and nonperipherally water-soluble tetra (quinoline 5-sulfonic acid) substituted metal-free (1, 2), Zn(II) (3, 4), Co(II) (5, 6), and Mn(III)Cl (7, 8) phthalocyanine (Pc) derivatives were reported.

Luận văn Thạc sĩ Hoá học: Phân tích cấu trúc của một số dẫn xuất quinoline-diketopiperazine bằng các phương pháp phổ hiện đại

tailieu.vn

Nhóm hợp chất quinoline. Nhóm hợp chất piperazinedion. Định tính phản ứng và kiểm tra độ tinh khiết của các hợp chất bằng sắc kí lớp mỏng. Phân tích cấu trúc của hợp chất theo sơ đồ 2.1. Quy trình phân tích cấu trúc của hợp chất theo sơ đồ 2.2. Phân tích cấu trúc của quinoline-piperazindinone. Phân tích cấu trúc của hợp chất 31. Phân tích cấu trúc của hợp chất quinoline-piperazindione 33. Phân tích cấu trúc của các hợp chất plinabulin. Phổ HSQC của một hợp chất hữu cơ.

Environmentally green synthesis of thioformamide derivatives

tailieu.vn

The thioacid derivatives 1 with isocyanides 2 in H 2 O reacted together in a 1:1 ratio at room temperature to produce thioformylamide derivatives 3a–d and thioformamide derivatives 4e–h (Scheme 1. Reactions of thiobenzoic acid with tert-butyl isocyanide, and thioacetic acid with benzyl isocyanide, 1,1,3,3-tetramethylbutyl isocyanide, and tertbutyl isocyanide produced thioformamide derivatives 4e–g.

Synthesis of fused tetrazolone derivatives

tailieu.vn

Abstract: New fused tetrazolone derivatives were synthesized using homophthalic and maleic anhydrides. The intermediates partially underwent internal 1,3-dipolar cycloaddition to produce fused tetrazolone derivatives.