- Identification of novel hub genes associated with gastric cancer using integrated bioinformatics analysis. - Background: Gastric cancer (GC) is one of the most common solid malignant tumors worldwide with a high- recurrence-rate. - To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. - The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. - https://doi.org/10.1186/s . - Gastric cancer (GC), the fifth most frequently diagnosed cancer and the third leading cause of cancer-related death [1], has become a major global health challenge.. - Gastric cancer microarray data information. - Overall, 183 patients with gastric cancer enrolled in this study.. - Information of DEGs’ protein experimental interactions and prediction was obtained by Search Tool for the Re- trieval of Interacting Genes (STRING, Version 11.0, http://www.string-db.org/) [10] with the parameters set to species = Homo sapiens, and PPI score ≥ 0.4 (medium confidence) [11]. - Subsequently, a specific PPI network of DEGs was constructed by cytoscape (version 3.7.2, http://www.cytoscape.org/) [12] based on the interac- tions retrieved from STRING. - In the. - In addition, the mo- lecular complex detection (MCODE) analysis (Version 3.7.2, http://apps.cytoscape.org/apps/MCODE) [13] in cytoscape was used to identify the significant modules of the PPI network with degree cut-off 2, max depth 100, k- core 2, and node score cutoff 0.2. - Lu et al. - Via R software, a total of 3224 DEGs (gastric cancer tissues vs. - Identification of the selected genes. - 4 PPI network of the DEGs in GC. - GC: gastric cancer. - Studies had shown that CCNB1 were associated with gastric cancer [36, 37]. - survival in gastric cancer patients [58]. - 10 Validation of 7 selected gene expression in gastric cancer samples was performed by qRT-PCR analysis. - GC: Gastric cancer. - The online version contains supplementary material available at https://doi.. - org/10.1186/s . - Bray F, et al. - 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