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Cell cycle arrest

Tìm thấy 20+ kết quả cho từ khóa "Cell cycle arrest"

Promotion of cell cycle arrest and inhibition of anchorage independent growth of cervical cancer HeLa cells by ethanol extract of croton kongensis

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Promotion of Cell Cycle Arrest and Inhibition of Anchorage-independent Growth of Cervical Cancer.

Achillea millefolium L. ethyl acetate fraction induces apoptosis and cell cycle arrest in human cervical cancer (HeLa) cells

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Achillea millefolium Phenolic compounds Apoptosis Cell cycle arrest. The cell cycle pro fi le and apoptosis analysis of the EtOAc fraction was studied in HeLa cells. millefolium, which may be a promising and valuable source of natural antioxidant and anticancer agents to be used in the development of new functional and therapeutic compounds in the future.. Cancer is considered one of the most lethal ailments worldwide..

Methoxy-stilbenes downregulate the transcription of Wnt/ β-catenin-dependent genes and lead to cell cycle arrest and apoptosis in human T98G glioblastoma cells

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The results of this study suggest that such an association occurs also in GBM cells, since the most ef fi cient inhibitor of the expression of Wnt target genes tri-MS - was also shown to be the most potent inducer of cell cycle arrest in the S phase and apoptosis. In our previous study naturally occurring 3,5,4 0 -tri-MS in contrast to 3,4, 4 0 -tri-MS in our current study, caused a massive accumulation of T98G cells at the G2/M phase of the cell cycle [18].

LCM and RNA-seq analyses revealed roles of cell cycle and translational regulation and homoeolog expression bias in cotton fiber cell initiation

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Fiber cell differentiation (left): Cell cycle arrest occurs in a subset of epidermal cells that are differentiating into fiber cells (blue boxes marked by X). Fiber cell initiation (middle): Upregulation of putative ribosomal protein subunit genes induces ribosome biosynthesis in early fiber cells (red boxes marked by X). Fiber cell elongation (right): Increased ribosome activities may promote translation for fiber cell elongation (red elongated boxes).

MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma

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Beyond Cell Cycle Arrest. https://doi.. Cell cycle and apoptosis

Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line

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FX-9 exposure increases the cell cycle inhibitor CDKN1A, which en- codes protein p21, providing multiple functions, for ex- ample, cell cycle arrest in response to drug induced DNA-damage [35]. Inhi- biting these can provide a G1 cell cycle arrest and suppression of DNA replication [45, 46]. Tumor cells could escape from cell cycle arrest and re-enter the cell cycle (mitotic slippage), usually resulting in those senescent cells or cell death in the G1-phase [53].

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2)

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The loss of p53 function abrogates these checkpoints and enables tumor cells to escape cell cycle arrest, senescence, or apoptosis despite accumulation of mutations and aberrant passage through the cell cycle.

Dual targeting of MEK and PI3K efectively controls the proliferation of human EGFR-TKI resistant non-small cell lung carcinoma cell lines with diferent genetic backgrounds

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It was also observed that the synergistic effects of the dual inhibition of upstream signal EGFR/MET and down- stream signal MEK/PI3K on the NSCLC were profound regarding growth inhibition, apoptosis, cell cycle arrest, Table 2 Effect of MEK162/BKM120 combination and BIBW2997/. ARQ197 combination therapy on NSCLC H1975, H460, and A549 cell cycle distribution.

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 20)

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Michaloglou C et al: BRAF E600 -associataed senescence-like cell cycle arrest of human naevi. Nature PMID: 16079850]. Soda M et al: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature PMID: 17625570]. Willet CG et al: Direct evidence that VEGF-specifi antibody bevacizumab has antivascular effects in human rectal cancer

Identification of functional regulatory elements in the human genome using pooled CRISPR screens

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We demonstrate that pooled CRISPR screens are cap- able of distinguishing p53-bound regulatory elements that influence cell proliferation and/or cell cycle arrest in response to DNA damage. Im- portantly, orthogonal experimental approaches were able to confirm the functional significance for several of these intergenic regulatory elements..

Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells

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Thus, we may conclude that FMNL2 silencing inhib- ited cell proliferation in human breast cancer cells.. FMNL2 silencing inhibited EdU incorporation and induced cell cycle arrest in human breast cancer cells. Therefore, our findings demonstrated that FMNL2 silencing inhibited EdU in- corporation and induced cell cycle arrest in human breast cancer cells.. FMNL2 overexpression elevated cell proliferation in human breast cancer cells.

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway

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Our study showed that NR1D1 arrested cell cycle at G1 phase and decreased the levels cell cycle- associated proteins, such as cyclins, indicating that cell cycle arrest induced by NR1D1 may contribute to its role in ovarian cancer growth. On the other hand, apoptosis was induced by NR1D1 over-expression, which may contribute to the tumor-suppressor role of NR1D1 in ovarian cancer. 4 NR1D1 inhibited the growth of ovarian cancer cells in vivo.

Oncogenic role of ALX3 in cervical cancer cells through KDM2B-mediated histone demethylation of CDC25A

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Experimentally, high expression of CDC25A was validated in the acquired CSCC cell lines. Further downregulation of CDC25A suppressed proliferation but induced cell cycle arrest at S phase in ME18 and C33A cells. The high-expression profile and the oncogenic role of CDC25A has been largely reported. For instance, downregulation of CDC25A reduced proliferation and cell cycle progres- sion of liver cancer cells [22], breast cancer cells [23], and so forth.

Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma

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Co-treatment with JQ1 and TEM induces cell cycle arrest and apoptosis. To determine combined effects of JQ1 and TEM on cell cycle and apoptosis, two highly MYCN-amplified NB (SK-N-BE2, SK-N-DZ) cell lines were treated with a sub- optimal concentration of each inhibitor alone or in com- bination and subjected to cell cycle and apoptosis analyses using propidium-iodide and Annexin-V stain- ing, respectively, followed by flow cytometry.

Tách chiết có hỗ trợ của siêu âm và hoạt động kháng ung thư của Piceatannol từ hạt chanh leo (Passiflora edulis)

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Anticancer activity of piceatannol in three human cancer cell lines Cell line Cytotoxicity* (IC 50 , µg/ml) ROS** (Fold) Cell cycle arrest. ***Cell cycle at which certain phases are arrested in the specific point of cell division cycle.. In addition, the anticancer activity of piceatannol extract powder was tested and confirmed by inhibition of migration (Figure 4)..

Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence

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Dauer-dependent re- modeling of the extracellular matrix may convey import- ant cues necessary for stem cell cycle arrest. could interact with components of the basement mem- brane [73] affecting its activity. These genes were of interest because of the implications of the TOR-mediated growth signalling pathway in the maintenance of germline quiescence during dauer.

Anticancer activities of stichoposide D isolated from the sea cucumber stichopus chloronotus on ntera-2 cancer stem cells

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Echinoside A and Ds- echinoside A, which are triterpenoid glycosides isolated from Peasonothuria graeffei, caused the arrest of the cell cycle during the G0/G1 phases in HepG2 hepatocarcinomas (Zhao et al., 2012). Cucumarioside A2–2 (Cucumaria japonica) was also reported with its anticancer effects through causing cell cycle arrest during the DNA synthesis (S) in Ehrlich carcinoma mouse tumor cells (Menchinskaya et al., 2013)..

Diapause in a tropical oil-collecting bee: Molecular basis unveiled by RNA-Seq

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Cell cycles in embryos of the silkworm, Bombyx mori: G2-arrest at diapause stage. G0/G1 cell cycle arrest in the brain of Sarcophaga crassipalpis during pupal diapause and the expression pattern of the cell cycle regulator, proliferating cell nuclear antigen. Cell cycle regulation during development and dormancy in embryos of the annual killifish Austrofundulus limnaeus. Atypical rho GTPases of the RhoBTB subfamily: roles in vesicle trafficking and tumorigenesis.

LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma

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Another study revealed that the predominant dysregulated pathways related to MANCR in regulating anaplastic thyroid cancer are relevant to mitosis and cell cycle [13]. It was found that MANCR was significantly enriched in cell cycle, apop- tosis and p53 signaling pathways. Our results indicated that silencing MANCR induced cell cycle arrest, cell division inhibition, and promoted cell apoptosis.

Examining the involvement of Slx5 in the apoptotic response to chronic activation of the spindle assembly checkpoint

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In the presence of improper attachment(s), SAC activation leads to a cell cycle arrest in metaphase until the attachment error is corrected before the cell proceeds to anaphase, thus prevents aneuploidy in daughter cells (Lara-Gonzalez et al., 2012). Since SAC activation prevents cell proliferation by inducing a mitotic arrest in response to improper kinetochore-microtubule attachments, microtubules represent one of the most successful chemotherapeutic targets in clinic today.