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Cell cycle progression

Tìm thấy 14+ kết quả cho từ khóa "Cell cycle progression"

Long non-coding RNAs HERH-1 and HERH-4 facilitate cyclin A2 expression and accelerate cell cycle progression in advanced hepatocellular carcinoma

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cycle progression by absorbing miR-29b/c.

MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma

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Beyond Cell Cycle Arrest. https://doi.. Cell cycle and apoptosis

Improved recovery of cell-cycle gene expression in Saccharomyces cerevisiae from regulatory interactions in multiple omics data

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This is consistent with the finding that cell- cycle genes, particularly those involved in the G1-S phase transition, are needed for heat-shock response [34]. Additional file 6: Table S6), consistent with the view that the metabolic status of the cell determines cell cycle progression [18]. Interaction between TFs important for recovering cell- cycle expression.

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2)

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Therapeutic Approaches to Cell Cycle Abnormalities in Cancer. The cell cycle is divided into four phases. The other three phases of the cell cycle are called interphase: G 1 (gap 1), during which the cell determines its readiness to commit to DNA synthesis. Deregulation of the molecular mechanisms controlling cell cycle progression is a hallmark of cancer.

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 13)

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Cancer stem cells, like their normal counterparts, have unlimited proliferative capacity and paradoxically traverse the cell cycle at a very slow rate. Slow cell cycle progression, plus high levels of expression of anti-apoptotic Bcl-2 family members and drug efflux pumps of the MDR family, render cancer stem cells less vulnerable to cancer chemotherapy or radiation therapy.

Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line

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Antimitotic drugs disrupt the cell cycle progression of tumor cells. The purpose of the cell cycle is to du- plicate the DNA accurately and to segregate the cop- ies into two identical daughter cells. In brief, the cell cycle is divided into G1-phase, S-phase, G2-phase and M-phase. If a checkpoint is activated, for example, due to DNA damage, the cell cycle is arrested until either DNA repair or programmed cell death occurs [10].

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4)

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Akt phosphorylates target proteins that promote resistance to apoptosis and enhance cell cycle progression, while mTOR and its target p70S6K upregulate protein synthesis to potentiate cell growth. Activation of PLC-γ leads the formation of. diacylglycerol (DAG) and increased intracellular calcium, with activation of multiple isoforms of PKC and other enzymes regulated by the calcium/calmodulin system.

Oncogenic role of ALX3 in cervical cancer cells through KDM2B-mediated histone demethylation of CDC25A

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Downregulation of CDC25A in ME180 and C33A cells reduced cell proliferation and blocked cell cycle progression, and it increased cell apoptosis. ALX3 was a positive regulator of CDC25A through transcription promotion. Overexpression of ALX3 in cells blocked the inhibitory effects of CDC25A silencing. cell cycle. The following analyses predicted that ALX3 is a highly potential transcription regulator of CDC25A.

Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells

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It used a dataset of 7 different tamoxifen- resistant breast cancer cell lines. TamR cells showed G1/S cell cycle progression and EGFR overexpression. To confirm the resistance to tamoxifen in TamR cells, we performed a cell viability assay after treatment with various concentrations of 4-OH-TAM in MCF-7 and TamR cells. This result indicates that TamR cells acquired resistance to tamoxifen. The cell cycle of MCF-7 and TamR cells was analysed using flow cytometry.

Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity

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Next, to identify transcription factor regulators of the refractory blast gene expression signature, which may serve as candidate therapeutic targets, we performed an in silico analysis using Enrichr [7, 28], a bioinformatics resource which facilitates analysis of experimentally de- rived gene sets. several of the most highly correlated genes were regula- tors or markers of cell cycle progression (CCNB2, MKI67, TPX2 &.

Genome-wide localization of the polyphenol quercetin in human monocytes

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Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis.. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity.

Chapter 081. Principles of Cancer Treatment (Part 18)

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Bortezomib is an inhibitor of the proteasome, the multi-subunit assembly of protease activities responsible for the selective degradation of proteins important in regulating activation of transcription factors, including NFκB and proteins regulating cell cycle progression. during the pathogenesis of a tumor by causing demethylation of the methylated cytosines that are acquired as an "epigenetic".

Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro

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MCF7 and T47D cell lines were used to compare the effect of USP7 with the p53 protein pathway as approximately half of cancer patients carry the mutant p53 protein (Gasco et al., 2002), which has been correlated with poor prognosis in breast cancer patients (Lai et al., 2004).. Ubiquitination and deubiquitination of proteins control various cellular mechanisms such as cell cycle progression (King et al., 1996) and regulation of transcription factors (Ciechanover, 2013).

Nghiên cứu tinh sạch và xác định tiềm năng chống ung thư của Piperine từ Hồ tiêu đen (Piper nigrum L.)

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Okwute S.K., Egharevba H.O.(2013), “Piperine type amides: Review of the chemical and biological characteristic”, International Journal of Chemistry, Vol.5, No.3, pps . (2006), “Asymmetric routes to substituted piperidines”, Chemical communication, Vol.6, Issue 6, pps. (2012), “Piperine impairs cell cycle progression ADN causes reactive oxygen species-dependent apoptosis in rectal cancer cells”, Experimental and molecular pathology, Vol.94, Issue 1, pps.109–114.. (2006), “Combined estrogen and testosterone

Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation

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Percentage of Cell cycle entry and cell cycle. Cell cycle Analysis. Cell cycle entry and distribution of WT and arid4b∆ mESCs.. Bar graph representation of Ki-67 positive WT and arid4b∆ mESCs. Cell cycle phase distribution of Ki67-positive WT and arid4b∆. FlowJo cell cycle analysis of e. WT and f. Black line represents the experimental analysis, while pink trace is cell cycle fit determined by the FlowJo software cell cycle suite.

A novel ferroptosis-related gene signature associated with cell cycle for prognosis prediction in patients with clear cell renal cell carcinoma

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Further functional enrichment analysis revealed that our FRG score might involve in pathways associated with the process of cell cycle in ccRCC. It was reported that ferroptosis could be regulated by p53, which was an indispensable regulator of the cell cycle and could enhance ferroptosis by inhibiting SLC7A11.

LncRNA DLGAP1-AS2 regulates miR-503/ cyclin D1 to promote cell proliferation in non-small cell lung cancer

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Downregulation of miR-503 promotes ESCC cell proliferation, migration, and invasion by targeting cyclin D1. MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression. MicroRNA-503 suppresses pro- liferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1

Lecture Principles of Biology - Chapter 12: The Cell Cycle

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Draw a circle diagram of the eukaryotic cell cycle. organizes between the two poles (opposite ends) of the cell. include vesicularization of the nuclear membrane and attachment of. midplane of the cell (the metaphase plate). sister chromatids. each has an identical copy of the genetic information

Methoxy-stilbenes downregulate the transcription of Wnt/ β-catenin-dependent genes and lead to cell cycle arrest and apoptosis in human T98G glioblastoma cells

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The investigation of the methylation status of the MGMT promoter in T98G cell line demonstrated that this cell line contains both methylated and unmethylated DNA at this locus [55]. In this context the analyzed compounds inhibited the transition of the cell cycle from the S phase to G2/M phase.

LCM and RNA-seq analyses revealed roles of cell cycle and translational regulation and homoeolog expression bias in cotton fiber cell initiation

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Translational regulation in early cotton fiber cell development. 5 Effects of ribosome biosynthesis and cell cycle inhibitors on fiber cell development. These results support the hypothesis that cell cycle attenuation and active ribosome biosynthesis promote fiber cell initiation and elongation.. Down- regulation of the ABA regulator and receptor genes may promote fiber cell initiation and elongation..