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Fat deposition

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Consensus module analysis of abdominal fat deposition across multiple broiler lines

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Our study also provides an idea for investigating the molecular mechanism of abdominal fat deposition across multiple broiler lines.. Keywords: WGCNA, Broiler, Abdominal fat deposition, Lipid metabolism, Autophagy. abdominal fat deposition [3]. Excessive abdominal fat deposition not only wastes feed to producers but also in- creases risk to human health [4, 5].

Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition

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Crossing of sheep breeds with different patterns of fat deposition is one of the agronomical strategies for improving the meat qual- ity. To investigate the genetic profiles of fat tissues and to understand the differences in the genetic mechanisms determining fat deposition between distinct breeds, we characterized the transcriptome of PEF, SUF, and TAF from GLT and STH sheep breeds..

Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens

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Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens. 0.05) and serum and AF testosterone levels decreased significantly ( P <. 0.01) after caponization. In AF tissue, 90 differentially expressed genes related to lipid metabolism were screened by gene expression profiling in caponized and sham-treated chickens. In vitro, Fat content was significantly lower in cells treated with testosterone compared with control cells ( P <.

A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens

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The discovery of QTL associated with fat deposition in the carcass allows the identification of positional candidate genes (PCGs) that might regulate fat deposition and be useful for selection against excess fat content in chicken ’ s carcass. Among these, four QTL were novel, while five have been previously reported in the literature.. We used sequence information from founder animals to detect 4843 SNPs in the 13 PCGs..

The whole-transcriptome landscape of muscle and adipose tissues reveals the ceRNA regulation network related to intramuscular fat deposition in yak

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Differentially expressed mRNAs during intramuscular fat deposition. Fig 1 The dynamics in the live weight (a) and the intramuscular fat (IMF) content (b) across and 7.5-year-old of age.. Similarly, after comparison of the data between the 0.5- and 2.5-year-old AA tissues, 72 DEGs were obtained, of which 39 were upregulated and 33 were downregulated (Fig. These results indicated that these 16 DEGs may have a role in the regulation of IMF- deposition development..

Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle

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The fat deposition is a consequence of the balance between energy intake and expenditure.

IRLnc: A novel functional noncoding RNA contributes to intramuscular fat deposition

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More- over, the results showed that IRLnc and NR4A3 were. 6 Fold changes of Sec61B and NR4A3 . b Expression of Sec61B and NR4A3 in IRLnc silent cells and normal cells. 7 In situ colocalization of IRLnc and NR4A3 mRNA in myoblast and the potential effect pathway of IRLnc on fat deposition ( n =3). f Potential effect pathway of IRLnc on lipolysis. mechanism of the candidate LincRNA and its down- stream gene..

Genomic analysis of worldwide sheep breeds reveals PDGFD as a major target of fat-tail selection in sheep

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Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition. Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection

Candidate gene screening for lipid deposition using combined transcriptomic and proteomic data from Nanyang black pigs

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A: Oil red O staining using frozen LD samples from each of the 6 pigs, HF: high-fat deposition group, LF: low-fat deposition group. B: Statistical analysis of the ratio of Oil red O-stained regions using students ’ T test. B: Heat map of the DEGs in the different lipid deposition groups. Validation of the transcriptome via qRT-PCR. The expression trends for all 14 genes in the LD tissues were consistent with the results of the transcriptome analysis.

Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs

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Pathways related to fat deposition, including fatty acid biosynthesis, steroid bio- synthesis, biosynthesis of unsaturated fatty acid and adipo- cytokine signalling pathways, were revealed in the comparison between 120 d and 240 d. The fatty acid bio- synthesis pathway was also significantly enriched in 400 d, but most of the DEGs were down-regulated..

Comprehensive analysis of differentially expressed circRNAs and ceRNA regulatory network in porcine skeletal muscle

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DEcircRNA host genes were concentrated predominately in TGF- β , MAPK, FoxO, and other signaling pathways related to skeletal muscle growth and fat deposition. The constructed ceRNA network plays a vital role in skeletal muscle growth and development, and fat deposition. miR-23b and SESN3 were found to participate in skeletal muscle growth regulation, also playing an important role in fat deposition.

Embryonic transcriptome and proteome analyses on hepatic lipid metabolism in chickens divergently selected for abdominal fat content

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As mentioned above, we found that genes/proteins related to lipid transport and energy metabolism were differentially expressed in the embryonic liver between the fat and lean lines. Molecular differences related to lipid transport, lipid clearance and energy metabolism exist for hepatic lipid metabolism at embryonic stages between the fat and lean chicken lines, which might contribute to the striking differences of abdominal fat deposition at post-hatch stages..

Comparative analysis of gene expression profiles in differentiated subcutaneous adipocytes between Jiaxing Black and Large White pigs

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A better understanding of the genetic regulation network of subcutaneous fat tissue is necessary for the rational selection of Chinese domestic pig breeds. In the present study, subcutaneous adipocytes were isolated from Jiaxing Black pigs a Chinese indigenous pig breed with redundant subcutaneous fat deposition and Large White pigs a lean-type pig breed with relatively low subcutaneous fat deposition.

Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus)

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In response to fasting, transgenic mice overexpressing SIRT6 gene attenuated excess fat deposition due to the reduction of PPARγ gene [9]. These results re- vealed that SIRT6 gene acted as a critical enzyme for the maintaining of lipid metabolism, which may be closely re- lated to fat deposition in mammals..

Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle

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Glucose metabolism and inflammation processes were the main pathways found in silico to influence intramuscular fat deposition in beef cattle in the integrative mRNA-miRNA co-expression analysis.. How- ever, little attention has been paid to the role of microRNAs in the regulation of IMF deposition in cattle..

Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 5)

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Patients with ectopic ACTH syndrome generally exhibit less marked weight gain and centripetal fat redistribution, probably because the exposure to excess glucocorticoids is relatively short and because cachexia reduces the propensity for weight gain and fat deposition. The ectopic ACTH syndrome is associated with several clinical features that distinguish it from other causes of Cushing's syndrome (e.g., pituitary adenomas, adrenal adenomas, iatrogenic glucocorticoid excess).

MicroRNAs and their regulatory networks in Chinese Gushi chicken abdominal adipose tissue during postnatal late development

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These results expand the number of miRNAs expressed in abdominal adipose tissue and pro- vide a valuable resource for the selective breeding of ab- dominal fat traits in chickens.. The dy- namic change in abdominal fat deposition in Gushi chicken is largely consistent with the cellular basis of ab- dominal adipose tissue development described in.

Genome Association Study for Visual Scores in Nellore Cattle Measured at Weaning

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The gene STK3 (known in humans as MST2) acts as a repressor of genes involved in the fat deposition of Han- woo bovines. The genes MAPK11 and MAPK12 are part of the metabolic pathway p38 MAPK, which is a preserved mechanism of cellular response to a broad variety of extracellular signals, and is proposed as a regulator of cellular differentiation, proliferation and development [48].

Modified-ramped position: A new position for intubation of obese females: a randomized controlled pilot study

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In obese patients, there is increased fat deposition in the chest wall, espe- cially in the back, which consequently increases the antero-posterior chest diameter.

Identification of diverse cell populations in skeletal muscles and biomarkers for intramuscular fat of chicken by single-cell RNA sequencing

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Fat deposition in the broiler chicken: a review. Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types. Evaluation of the effect of static magnetic fields combined with human hepatocyte growth factor on human satellite cell cultures. Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration.