Có 18+ tài liệu thuộc chủ đề "Lipid metabolism"
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Global investigation of estrogen-responsive genes regulating lipid metabolism in the liver of laying hens. In chickens, estrogen is critical for lipid metabolism in the liver. Integrated analysis of the data of RNA-Seq and ChIP-Seq, identified 191 genes directly targeted by estrogen, including 185 protein-coding genes, 4 miRNAs, and 2 lncRNAs. Conclusions: These results increase our understanding of the functional network...
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Integrated analysis of the methylome and transcriptome of chickens with fatty liver hemorrhagic syndrome. Fatty liver hemorrhagic syndrome (FLHS) is a serious disease and is tightly linked to lipid homeostasis. Keywords: DNA methylation, RNA-seq, Fatty liver hemorrhagic syndrome, Lipid metabolism, Cellular junction and communication. For chickens, fatty liver hemorrhagic syndrome (FLHS) is a serious disease, which is characterized by massive...
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Quantitative trait loci analysis can be used to identify those genetic differences between two strains of the same species that are responsible for the differences in a given phenotype. Whole genome sequencing of this subpopulation and of the unsorted pool of segregants implicated several loci that are involved in lipid accumulation. Three of the identified genes, PIG1 , PHO23 and...
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Consensus module analysis of abdominal fat deposition across multiple broiler lines. Background: Despite several RNA-Seq and microarray studies on differentially expressed genes (DEGs) between high- and low-abdominal fat deposition in different broiler lines, to our knowledge, gene coexpression analysis across multiple broiler lines has rarely been reported. Here, we constructed a consensus gene coexpression network focused on identifying consensus gene...
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Combined transcriptome and proteome profiling of the pancreatic β -cell response to palmitate unveils key pathways of β -cell lipotoxicity. To unravel critical mediators of lipotoxicity upstream of the palmitate-modified genes, we identified overrepresented transcription factor binding sites and performed network inference analysis. The images or other third party material in this article are included in the article's Creative Commons...
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Background: The AMP-activated protein kinase (AMPK) is an intracellular fuel sensor for lipid and glucose metabolism. In this study, RNA interference (RNAi) was conducted to investigate the effects of knockdown of TcAMPK α on lipid and carbohydrate metabolism in the red flour beetle, Tribolium castaneum, and the transcriptome profiles of dsTcAMPK α -injected and dsEGFP-injected beetles under normal conditions were...
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Transcriptional profiling of PPAR α. and CREB3L3. regulation of hepatoproliferative and metabolic functions of PPAR α. Background: Peroxisome Proliferator-Activated receptor α (PPAR α ) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. A small number of genes, including Fgf21 and Mfsd2a, were under dual control of PPAR...
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Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens. 0.05) and serum and AF testosterone levels decreased significantly ( P <. 0.01) after caponization. In AF tissue, 90 differentially expressed genes related to lipid metabolism were screened by gene expression profiling in caponized and sham-treated chickens. In vitro, Fat content was significantly lower in cells treated with...
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Results: We performed transcriptome and proteome profiling on chicken livers at five embryonic stages (E7, E12, E14, E17 and E21) between the fat and lean chicken lines. At each stage and 169 differentially expressed genes were found by the digital gene expression, respectively, which were significantly enriched in the metabolic, PPAR signaling and fatty acid metabolism pathways. Quantitative proteomics analysis...
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The whole transcriptome effects of the PPAR α agonist fenofibrate on livers of hepatocyte humanized mice. The aim of the present study was to better characterize the impact of PPAR α activation on gene regulation in human liver. To that end, chimeric mice containing hepatocyte humanized livers were given an oral dose of 300 mg/kg fenofibrate daily for 4 days....
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However, the specific metabolic changes in the liver under conditions of limit-feeding remain unclear and require further study. Moreover, the ruminal fermentation profiles, growth characteristics, and levels of metabolites in the liver and plasma of the heifers were monitored.. Nine DEGs were enriched in the related pathways, namely HMGCS1 , HMGCR , MSMO1 , MVK , MVD , IDI1 ,...
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Diet is, therefore, the indispensable factor that influences the ability to lose weight or maintain body weight (Keränen et al., 2009. Anders in Malaysia (Alsarhan et al., 2014). It is widely distributed in Peninsular Malaysia, Thailand, Myanmar, and India (Mackeen et al., 2000. Hamidon et al., 2017). Almost all parts of the tree such as fruit, leaves, roots, and stem...