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MDA-MB-231 breast cancer cell line

Tìm thấy 20+ kết quả cho từ khóa "MDA-MB-231 breast cancer cell line"

Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line

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Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line. italica) belongs to the Brassicaceae family and is one of the most important crucif- erous vegetables. The antiapoptotic activity of sulforaphane treatments was evaluated and tested using MDA-MB-231 breast cancer cell line. The highest amount of sulforaphane was produced at 80 μM SA and 40 μM MeJA after 24 h of elicitation.

Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway

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BMC Cancer https://doi.org/10.1186/s . Human breast cancer cell lines MCF7 and MDA-MB- 231, and human colon carcinoma cell line HCT116 were obtained from the American Type Culture Collection (ATCC, Manassan, VA, USA). UEV1A -overexpressed stable MDA-MB-231 and MCF7 cell lines were created as previously reported [6].

Effect of Propofol on breast Cancer cell, the immune system, and patient outcome

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To understand the biology of breast cancer, breast cancer cell lines have been established and widely used to investigate the effect of drugs on cancer cell proliferation, apoptosis, migration and invasion. To date, more than 51 breast cancer cell lines have been separated from primary tumor, and successfully cultured in vitro [12]. MDA-MB-468 and MDA-MB-231 both belong to triple negative breast cancer cell lines.

Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin

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The breast cancer cell line MDA-MB-231 but also human NSCLC cancer cell lines NCI-H460 and NCI-H1299 were treated with 10 μM Alectinib as above (II). After washing, cells were treated with 150 μM 5-ALA for 3 h. of the NCI-H460, 18% of NCI-H1299 and 26% of the MDA-MB-231 cells were positive for Annexin V- FITC staining (Fig.

Doxorubicin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells, opposite to its effects on MDA-MB-231 cells

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Earlier studies reported that DOX downregulates PD-L1 expression on the cell surface of MDA-MB-231 breast cancer cells (Ghebeh et al., 2010). Because the DOX effect on PD-L1 expression in CRC cells is not known, we investigated the expression level of PD-L1 on DOX treatment in HCT116 colon cancer cells. We found that PD-L1 expression increased positively in DOX-treated HCT116 colorectal cancer cells and decreased in MDA- MB-231 breast cancer cells both in RNA and protein levels (Figure 1).

The expression of kappa-opioid receptor promotes the migration of breast cancer cells in vitro

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Here, the breast cancer cell lines of MDA-MB-231 and MCF-7 were chosen to detected the function of OPRK1 in migration of breast cancer, as MDA-MB-231 cells with high expression of OPRK1 while the expression of OPRK1 in MCF-7 was low. Previous studies showed that the migration ability was stronger in MDA-MB-231 cells than MCF-7 cells [22], and our results suggested the overexpression of OPRK1 might be associated with the migration ability of breast cancer cells.

A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells

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The cytotoxic activity of compound 2-[1-piperonylpiperazine- 1-yl]-3-chloro-1,4-naphthoquinone was previously investigated in several cancer cell lines including MCF-7 cells and promising results were published (Deniz et al., 2015). of the compound in a TNBC subtype cell line, MDA- MB-231. As shown in Figure 2, the compound decreased cell viability in both MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner.

Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells

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Compared to lower proliferative cells MCF7 and T47D, FMNL2 was overexpressed in highly proliferative breast cancer cells MDA-MB-231, BT549 and SUM159, accompanied by reduced levels of p27 and p21, and elevated CyclinD1 and Ki67 expression. FMNL2 silencing significantly inhibited the cell proliferation of MDA-MB-231 and BT549 cells. Meanwhile, FMNL2 overexpression distinctly promoted the cell proliferation of MCF7 cells.

Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC010

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.- com [9], the conventional cell line model of DCIS, and to the widely characterized breast cancer cell lines, MCF-7, a hormone-receptor positive breast cancer model [15, 16], MDA-MB-231, a triple-negative breast cancer model [4], and the immortalized, breast epithelial cell line MCF-10A [17]..

Transcriptional splice variants of CD40 and its prognostic value in breast cancer

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Cell culture:BT-474, HCC-38, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3, T-47D, ZR-75-1 breast cancer cell lines and MCF-12A healthy mammary epithelial cell line were cultured in RPMI medium containing L-glutamine (2 mM), 10% fetal bovine serum (Biological Industries, Cromwell, CT, USA), penicillin (100 unit/mL) and streptomycin (100 mg/mL. data of the CD40 gene from all of the cancer cell lines were downloaded and a total of 66 breast cancer cell lines were selected.

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes

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We hope these data resources as well as our analyses will be broadly used in the breast cancer research community for mechanistic studies, biomarker discovery and precision therapy.. When cells reached 60% confluence, two siRNAs targeting AFAP1-AS1 (ThermoFisher Scientific, Cat. MDA-MB-231, HCC1937 cells were transfected with control siRNA, or siRNA targeting AFAP1-AS1. Chromatin state model.

Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis

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Treatment with propofol at equipotent and clinically relevant doses had no significant effect on breast cancer cell viability (Fig. To evaluate the role of intracellular Ca 2+ homeostasis in the augmentation of breast cancer cell viability by sevo- flurane, we modulated intracellular and extracellular Ca 2+. The addition of BAPTA-AM Ca 2+ chelator dramatically reduced the viability of MCF7 and MDA-MB-436 breast cancer cell lines (MCF7 &.

In vitro physiological effects of Origanum onites L. (Lamiaceae) essential oil treatment on human origin cell lines

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To our knowledge, Spyridopoulou et al. against LoVo and SW620 human colon cancer (Aldisi et al., 2019) or MDA-MB-231 human breast cancer cell lines (Al Kahlout and Eid, 2014). Also, the ethanolic extract of Origanum majorana was reported to reduce the migration rate of the MDA-MB-231 cancer cell line (Al Dhaheri et al., 2013). Carvacrol which is the principal component of Origanum spp., Andoğan et al. et al., 2016. Fan et al., 2015. Jung et al., 2018. Trindade et al., 2019)..

Isolation and comparison of tumorigenicity of different cell populations from the MCF-7 breast cancer cell line based on cd44 and cd24 markers

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These results confirmed CD44 + CD24 -/dim cells were the strongest cell population causing tumour in breast cancer cells MCF-7.. Keywords: Breast cancer cells, MCF-7 cell line, Breast cancer stem cells, Tumorigenicity.

E2F6 is essential for cell viability in breast cancer cells during replication stress

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Holliday and Speirs, 2011), a difference between the cell lines is that the tumor type of MCF-7 cells is metastatic adenocarcinoma, while that of T-47D is invasive ductal carcinoma (Kao et al., 2009).. It is known that MDA-MB-231 is triple-negative, and its tumor type is metastatic adenocarcinoma (Kao et al., 2009).. Thus, different sensitivities to si-E2F6 might be because E2F6 shows cell-type specificity and target-gene selectivity (Oberley et al., 2003).

An insight into the therapeutic potential of piperazine-based anticancer agents

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Compound 131 (Figure 13) showed prominent antiproliferative activity against the HeLa, MDA-MB-231, and IMR32 cancer cell lines, having GI 50 values of and 0.83 µM. values of less than 0.01 µM against breast cancer and neuroblastoma cell lines. Among the new compounds, 134 showed the highest activity against the HeLa and MCF7 cell lines with IC 50 values of 14.05.

Secretion of BMP-2 by tumorassociated macrophages (TAM) promotes microcalcifcations in breast cancer

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Recent study has shown that macrophages are correlated with microcalcifications in benign lesions and breast cancer cells may undergo oste- oblast differentiation after co-culturing MDA-MB-231 with calcium oxalate and activate monocytes [33]. These results indicated that TAMs could be the cells that secrete BMP-2 and induce microcalcifications in breast cancer..

Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties

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According to the good biocompatibility of the investigated dyes and the potential for anticancer activity of compounds with similar structure shown in literature, 41 the antiproliferative activity of the investigated dyes against cancer cell lines HCT-116 and MDA-MB-231 has been tested. The assessment of the in vitro antiproliferative activity of the dyes against the human breast cancer MD-MB-231 cell line was performed, and the results are presented in Figure 6.

Nghiên cứu thành phần hóa học theo hướng độc tế bào trên dòng tế bào ung thư vú MDA-MB-468 của vỏ quả dó bầu (AQUILARIA CRASSNA Pierre ex Lecomte)

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Từ khóa: Dó bầu, Aquilaria crassna, độc tế bào, MDA-MB-468.. ISOLATION AND IDENTIFICATION OF CYTOTOXIC SAPONIN ON BREAST CANCER CELL LINE MDA-MB-468 FROM AQUILARIA CRASSNA Pierre ex. This study was conducted to investigate the cytotoxic effect on MDA-MB-468 breast cancer cell line of A.crassna fruit, isolation, determine the structure and cytotoxic effect of substances isolated.. Keywords: Aquilaria crassna, agarwood, MDA-MB-468, cytotoxic..

Summary of Biology dotoral thesis: Study on cytotoxic activity of some cancer cell lines of isolated compounds from three soft corals Sinularia nanolobata, Sinularia leptoclados, Sinularia conferta collected from the sea area of Central Vietnam

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Apoptosis rate under the influence of SCO 27 on lung cancer cell line A549. The rate of necrotic. SCO 27 - 5 µM . SCO 27 - 10 µM . Study on cytotoxicity mechanism of compound SLE 27 in breast cancer cell line MCF-7. Evaluation of the effect of SLE 27 on morphological change in cancer cells. Effects of compound SLE 27 at concentrations of 10, 30 and 100 µM on morphology of breast cancer cell line MCF-7. control - MCF-7 cells not supplemented with SLE 27 compound..