Có 80+ tài liệu thuộc chủ đề "cơ chế thần kinh"
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Garbern JY (2005) Pelizaeus-Merzbacher disease: pathogenic mechanisms and insights into the roles of proteolipid protein 1 in the nervous system. Garbern JY, Yool DA, Moore GJ, Wilds IB, Faulk MW, Klugmann M, Nave KA, Sistermans EA, van der Knaap MS, Bird TD, Shy ME, Kamholz JA, Griffiths IR (2002) Patients lacking the major CNS myelin protein, proteolipid protein 1, develop...
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Alzheimer’s disease (AD) is the most common cause of dementia in the elderly (Evans et al., 1989). Messier and Teutenberg, 2005), and the presence of multiple factors further increases the risk of AD (Luchsinger et al., 2005). These pathologies are associated with chronic inflammation and altered blood vessel responsiveness (Akiyama et al., 2000. Smith et al., 1997. Butterfield et al.,...
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was recently confirmed by others (Choi et al., 2004). Others showed that diminished proteasome function could lead to neurodegeneration (Halliwell, 2002) and oxidative stress (Ding et al., 2003). Neuropolypeptide h3 (NPH3), a phosphatidyloethanolamine-binding protein [PEBP] or cholinergic neurostimulating peptide, may play an important role in reg- ulating choline acetyl transferase (ChAT) and maintaining phospholipid asymmetry, a process that is important...
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Mondragón-Rodríguez et al.. Alzheimer disease (AD) is defined by insoluble filamentous aggregates known as senile plaques and neurofibrillary tangles (NFT), of which the major components are amyloid-β (Aβ) and tau protein, respectively (Wood et al., 1986. Arriagada et al., 1992. Goedert et al., 1998). Wang et al., 2004a,b. Lemos et al., 2009;. Zawia et al., 2009).. Oxidative stress has also...
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These findings establish a link between oxidative stress and mitochondria, cre- ating a pathological feedback loop, although in other cell types such as astrocytes, which are known to regulate glutathione availability, mitochondria are unaffected (Pope et al., 2008).. It has been reported that the neurons exhibiting increased oxidative damage in AD are coincident with striking and significant increase in cytochrome...
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Lemos RR, Castelletti C, Lima Filho JL, Marques ET, Oliveira JR (2009) In Silico Identification of New Genetic Variations as Potential Risk Factors for Alzheimer’s Disease in a Microarray- oriented Simulation. Lleo A, Greenberg SM, Growdon JH (2005) Current Pharmacotherapy for Alzheimer’s Disease.. Lopez-Bastida J, Hart W, Garcia-Perez L, Linertova R (2009) Cost-effectiveness of donepezil in the treatment of mild...
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Some adults with myotonic dystrophy type 1 (DM1) have been seen to develop dementia with aging, agreeing with recent studies doc- umenting an abnormal tau-protein expression in the brain tissues of patients with DM1 (Modoni et al., 2004). A possible distinct subclass of peripheral tauopathy has been postulated based on immunoblot studies (Maurage et al., 2004). 2 Biochemistry and Molecular...
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Glycation: Proteins with slow turnover rates can be modified at lysine residues by nonenzymatic reactions involving the condensation of a sugar aldehyde or ketone group with the NH2-groups of the lysines. The products of this reaction can undergo irreversible changes to form the advanced glycation end-products that can result in the cross-linking of the modified proteins. Tau isolated from PHF...
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The concomitant activation of kinases will inevitably lead to the phosphorylation of this pool of tau which is not bound to tubulin. This in turn prevents the further reattachment of tau to the microtubules and favors the formation of PHF typical of the NFTs.. It is now known that oxidative stress alone causes no increase in tau phosphorylation, but subtly...
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Mondragon-Rodriguez S, Basurto-Islas G, Santa-Maria I, Mena R, Binder LI, Avila J, et al.. Morris HR, Baker M, Yasojima K, Houlden H, Khan MN, Wood NW, et al. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S et al (1998) Frontotemporal lobar degeneration:A consensus on clinical diagnostic criteria. J Neurochem Riley DE, Lang AE, Lewis A, Resch...
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Durnam and Palmiter, 1981) and MT-III, which is most abundant in neurons that sequester Zn in synaptic vesicles (Bush et al., 1994). Klaassen et al., 1999. Trayhurn et al., 2000). Although the mechanism of transport of Zn from brain extracellular environments to intracellular compartments in neurons and glia is not completely understood, it is thought to involve members of the...
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Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. Danscher G, Howell G, Perez-Clausell J, Hertel N (1985) The dithizone, Timm’s sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS. Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, Juhl S, Stoltenberg M, Ravid R (1997) Increased amount of zinc in...
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AD incidence increases from 2.8 per 1000 person-years when 65–69 years and to 56.1 per 1000 person-years when older than 90 years (Kukull et al., 2002).. Serretti et al., 2005). Thirteen percent of these familial cases are inherited in an autosomal dominant manner with at least three generations affected (Brickell et al., 2006. Campion et al., 1999). Raschetti et al.,...
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mouse models with missense mutations of the endogenous murine PSEN1 and high Aβ42 levels perform poorly on the object recognition test (Huang et al., 2003. Janus et al., 2000). Double PSEN1/APP transgenics have been developed and suggest that PSEN1, APP, and mutations within these genes, play a role in the production of Aβ (Holcomb et al., 1998. Mineur et al.,...
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Fredenburg et al., 2007).. Ibanez et al., 2004). SNCA duplications are rarely asso- ciated with dementia (Fuchs et al., 2007. Nishioka et al., 2006). Duplications of SNCA (Chartier-Harlin et al., 2004. Ibanez et al., 2004. Golbe et al., 1990).. In addition, SNCA promoter polymorphisms have been associated with idiopathic PD disease risk (Maraganore et al., 2006. Pals et al., 2004....
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Expression of DJ1 is ubiquitous and abundant in most mammalian tissues includ- ing the brain, where it is found in both neuronal and glial cells (Bandopadhyay et al., 2004). Downregulation of endogenous DJ1 protein of the neuronal cell line by siRNA enhances oxidative stress-induced cell death, ER stress, and proteasome inhi- bition, but not by proapoptotic stimulus (Taira et al.,...
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Once shunned, test for Alzheimer’s risk headed to market. Cruts M, Van Broeckhoven C (1998) Molecular genetics of Alzheimer’s disease. Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA (2006) Structural basis for conformational plasticity of the Parkinson’s disease- associated ubiquitin hydrolase UCH-L1. De Marco EV, Annesi G, Tarantino P, Rocca...
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Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C, Carter DM, Zhu PP, Stadler J, Chandran J, Klinefelter GR, Blackstone C, Cookson MR (2003) L166P mutant DJ-1, causative for recessive Parkinson’s disease, is degraded through the ubiquitin-proteasome system. Mineur YS, McLoughlin D, Crusio WE, Sluyter F, Huynh LX (2005) Genetic mouse models of Alzheimer’s disease Social behavior...
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Morley et al., 1979. Oswald and Freeman, 1981) and one that binds the ligands [3H]-L-nicotine or [3H] acetylcholine with high affinity (Abood et al., 1980. Schwartz et al., 1982. Sershen et al., 1981). The two binding sites also were found to be expressed in overlapping yet distinct patterns in the brain (Clarke et al., 1985. Marks et al., 1986;. Nicotinic...
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This allele is linked to vari- ability in α7 expression in the hippocampus (Stitzel et al., 1996), neuroanatomical distribution of α7 nAChRs in the hippocampus (Adams et al., 2001), developmental expression of α7 nAChRs in the hippocampus (Adams et al., 2006), and audi- tory gating deficits (Stevens et al., 2001). The fact that the allele of Chrna7 that leads to...