Có 11+ tài liệu thuộc chủ đề "Cytotoxic activity"
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DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.. 2 This is also true for metal-containing drugs because of the metal-binding...
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Abstract: Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a–g) were synthesized and characterized by elemental analysis, 1 H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a–g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. The effects of substituents (–H, –CH 3 , and –I) and their positions (ortho, meta, and para) on the antiproliferative activities...
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Cytotoxic activities of the ligands and nickel(II) complexes were determined using the MTT assay in vitro against MDCK cells, and then all the compounds were tested on influenza virus replication by plaque assays. The effects of the compounds on the influenza virus and structure–antiviral activity relationships were discussed based on the donor atoms and S-alkyl substituents.. 5,6 In particular, the...
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1 H NMR (300 MHz, DMSO- d 6 ) (δ , ppm): 7.58 (dd, J 1 = 9, J 2 = 2.5 Hz, 1H), 7.67 (d, J = 8.4 Hz, 2H), 7.68 (d, J = 9 Hz, 1H), 7.93 (d, J = 2.5 Hz, 1H), 8.85 (d, J = 8.4 Hz, 2H). δ, ppm): 7.39 (d, J = 9 Hz,...
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2.65 (2H, t, J=10.8 Hz, piperidine H 6. N, 10.00. N, 10.14. 7.86 (2H, d, J= 1.2 Hz, phenyl H 5 +H 6. C 13 -NMR (100 MHz, DMSO) δ 177.7 (C=S), 156.6 (C=N), 149.7 (phenyl C 1. 134.9 (phenyl C 4. 132.4 (phenyl C 3. 131.8 (phenyl C 5. 127.7 (phenyl C 3 ’+C 5. 127.6 (phenyl C 4....
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only the more stable form of the isomeric mixed benzoins could be isolable in excess. When the carbonyl group is adjacent to the phenyl ring with the more electron- donating substituent, it is consistent with the reversibility of the reaction and the relative stability of the carbonyl groups in the possible products [16]. Thus, all of the mixed benzoin synthesis...
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Investigation of Cytotoxic Activity of Cyanobacterial Strains Isolated from Water and Soil Samples Collected in Hanoi. Abstract: As part of the ongoing efforts to exploit the pharmaceutical potential of domestic cyanobacteria, six strains belonging to the Nostocales order have been isolated from several sampling sites in Hanoi as prerequisite material. The cytotoxic activity evaluation based on the MTT test resulted...
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Synthesis and cytotoxic activity of some. All of the compounds were evaluated for their cytotoxic activity against MCF7, A549, HeLa, and HEK293 cell lines by real time cell analyzer. Cancer is known as one of the most lethal diseases as it is responsible for more than 20% of all deaths in developed countries. 1 High mortality rates, serious side effects,...
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Abstract: Investigation of the aerial parts of Cephalaria elazigensis var. Compound 2, named anemoclemoside A, which is an unusual triterpene glycoside, was identified in the family Dipsacaceae for the first time. Chemical structures of all compounds were determined on the basis of the HRESIMS and 1D and 2D NMR data. Saponins are a diverse group of compounds widely distributed in...
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FLAVONOIDS AND THEIR CYTOTOXIC ACTIVITY FROM TITHONIA DIVERSIFOLIA. Three flavones (1-3) were isolated from the aerial part of Tithonia diversifolia (Hemsl.) A. The compounds 1-3 showed cytotoxic activity against four human cancer (KB, Hep, Lu1 and MCF7) cell lines with IC 50 values ranging from g/mL to g/mL. Among them, compound 3 has shown the most potent effect on Hep...
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CYTOTOXIC ACTIVITY OF NEW PHENOLICS FROM DIANELLA ENSIFOLIA (L.) DC.. In our previous study, 10 compounds were isolated and structurally identified from the aerial part of Dianella ensifolia. Three of them (1, 2, and 4) were newly identified compounds and one (3) was obtained for the first time as natural product.With the aim to search for the cytotoxic agents from...