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HeLa cell

Tìm thấy 16+ kết quả cho từ khóa "HeLa cell"

Promotion of cell cycle arrest and inhibition of anchorage independent growth of cervical cancer HeLa cells by ethanol extract of croton kongensis

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Keywords: Croton kongensis, HeLa cells, zebrafish, cell cycle arrest, anchorage-independent growth..

Achillea millefolium L. ethyl acetate fraction induces apoptosis and cell cycle arrest in human cervical cancer (HeLa) cells

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Brie fl y, Cancer cell lines were seeded in 96-well plates and incubated in the respective medium at 37 °C, under 5% CO 2 , for 24 h. Different concentrations of the fractions were added and 100 μ g/ml). In order to study the effect of the fractions on apoptosis and cell cycle pro fi le, Hela cells were treated with the EtOAc fraction, after 24 h treatment, cells were trypsinized and centrifuged at 1200 rpm.. Cell cycle analysis.

Two new coordination polymers containing dicyanidoargentate(I) and dicyanidoaurate(I): synthesis and characterization, and a detailed in vitro investigation of their anticancer activities on some cancer cell lines

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In the present study, to test whether the mechanism of antiproliferative and cytotoxic activity of C1 and C2 involves apoptosis, we tested the DNA fragmentation potential of C1 and C2 on HeLa, HT29, and C6 cells.. The effect of C1 and C2 on HeLa cell migration. C1 and C2 at IC50 concentrations showed a suppressive effect on the migration of the HeLa cell line in a time-dependent manner (Figure 5). It is suggested that C1 and C2 have antimetastatic potential..

CeL-ID: Cell line identification using RNAseq data

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Cell line misidentification: the beginning of the end.. Check your cultures! A list of cross-contaminated or misidentified cell lines. Standards for cell line authentication and beyond. Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.. Cell-line authentication demystified. The genomic and transcriptomic landscape of a HeLa cell line.

Synthesis of novel 5-substituted phenyl-3-(p-isopropylphenyl)-1-phenylformazan and their biological activities

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The IC 50 and IC 75 values of the compounds against HeLa and C6 cell lines.. Compound name HeLa cell line C6 cell line IC 50 IC 75 IC 50 IC 75. Effects of different substituents at the ortho-position of compounds on their antiprolifera- tive activities against HeLa and C6 cell lines.

Doctor of Philosophy: Bioprospecting of haloarchaea for the development and expression of potent novel antioxidant enzymes

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Antiproliferative effect of SOD on cultured HeLa cell line. Plate 5.1: Antiproliferative effect of SOD on cultured HeLa cell line. Table 5.2: Antiproliferative effect of SOD against cultured MCF-7 cell lines. Figure 5.2: Antiproliferative effect of SOD against cultured MCF-7 cell lines 0. Table 5.3: Antiproliferative effect of SOD on cultured A-549 cell line. Figure 5.3: Antiproliferative effect of SOD on cultured A-549 cell line 0.

Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives

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In summary, a series of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole (3a–h) and 1,4-phenylene-bis- pyrazolylthiazole derivatives (5a–h) were synthesized and evaluated for their anticancer and cytotoxicity effects against C6 and HeLa cell lines. While compounds 3a–h showed potent and selective anticancer activity with low cytotoxicity values against C6 cell lines, they exhibited very low activity against HeLa cell lines.

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

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As a follow-up to these results, we aim at the synthesis of novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives from 1,4-phenylene-bis-chalcones, and we also investigate their anticancer activities against the C6 and HeLa cell lines..

E2F6 is essential for cell viability in breast cancer cells during replication stress

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Thus, different sensitivities to si-E2F6 might be because E2F6 shows cell-type specificity and target-gene selectivity (Oberley et al., 2003). Oberley et al. (2003) compared the occurrence of E2F6 in the promoter of its target gene (ART-27) between HEK293 and HeLa cells and found that the ART-27 gene promoter was enriched with E2F6 in the first cell line, but not in the second one, in spite of the higher levels of E2F6 protein being expressed in HeLa than HEK293 cells (Ogawa et al., 2002).

The employment of a conformal polydopamine thin layer reduces the cytotoxicity of silver nanoparticles

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It is commonly believed that AgNPs disrupt mitochondrial functions and result in cell cytotoxicity (Ahamed et al., 2008. Arora et al., 2009). The work by Ahamed et al.. Also, Arora et al. et al., 2012. Arrows indicate the thickness of the PDOP layer on the AgNPs.. Similarly, Kim et al. tested AgNPs of different particle sizes (10–100 nm) on the HeLa cell line (Kim et al., 2012).

An insight into the therapeutic potential of piperazine-based anticancer agents

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In this series, compound 24 (Figure 4) showed prominent activity against A549, HeLa, and SGC7901 cell lines, having IC 50 values of 5.24. Compounds 25 and 26 were prominent agents, having IC 50 values of µM and µM for 25 and µM and µM for 26 against cervical cancer lines HeLa and CaSki, respectively. Compound 27 exhibited promising anticancer effects against HeLa cell lines with IC 50. values of µg/mL. Compound 28 was most potent against the CaSki cell line, having IC 50 values of µg/mL.

Virus expression detection reveals RNAsequencing contamination in TCGA

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(SNPs) that were present in the genome of HPV18 in HeLa cells.

Investigation of cytotoxic activity of cyanobacterial strains isolated from water and soil samples collected in Hanoi

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All nine fractions were tested for cytotoxic activity against HeLa cell line at a 20 µg/mL concentration. The result showed that the fraction K3 inhibited 70% growth of HeLa cells (cells were shrunk or detached) (Figure 4B), while the other eight fractions had minor effects on the growth and shape of HeLa cells (Figure 4C)..

Design, synthesis, biological evaluation and molecular docking of novel molecules to PARP-1 enzyme

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For the chemosensitization assay, the HeLa cells were cotreated with a 10- µM dose of the compounds and 1.5- µM dose of doxo, and incubated for 24 h at conventional cell culture conditions. The PARP inhibitory activity of compounds was investigated by measuring the inhibition of the H 2 O 2 -induced PARylation in the HeLa cells [24].

A novel ROCK inhibitor: Off-target effects of metformin

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HeLa and MCF- 7 cells were seeded in 96-well plates. After 24 h, the cells were incubated with an appropriate concentration of tolbutamide and metformin for 1 h. Monitoring of cell proliferation after the treatment of tolbutamide and metformin using the xCELLigence system. Representative 3D pictures of HeLa cells treated with tolbutamide and metformin for 1 h. Representative 3D pictures of HeLa cells treated with tolbutamide and metformin for 24 h.

A case study on in vitro investigations of the potent biological activities of wheat germ and black cumin seed oil

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The concentrations of WGO of 0.1 mg/mL and lower did not show a decrease in the cell viability of all cell lines.. Necrotic and apoptotic rates in 0.5 mg/mL BCSO-treated HeLa cells were 66.7% and 8.9%, respectively (Figure 5B), and 69.8% of U87 cells were detected as necrotic after incubation with BCSO (Figure 5C). The anticancer effect of BCSO can be. Dose-dependent cytotoxic effects of BCSO on viability of A549 (A), HeLa (B), U87 (C), and NIH-3T3 (D)..

Cancer microcell initiation and determination

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The 1060 cells were counted in this study in each of the used cell lines— HeLa, HS-68, and SK-MEL-28 cells.. In the used HeLa and SK-MEL-28 cell lines under inves- tigation, the microcells (shown as blue dots in Fig. The microcells showed an increasing tendency in the cell population of the HeLa. (B) SK-MEL-28 PTX-treated cells, PhC. 2 Increase in the number of microcells after applied therapy.

Assessing cell-specific effects of genetic variations using tRNA microarrays

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In addition, karyotypes of both HeLa and HEK293 are largely divergent from a human cell line, due to viral immortalization of HEK293 and natural integration of the human papilloma virus in the HeLa model.. GCG, CUA, CAU), while some were equivalent regardless of the model be- ing tested (e.g. Codons falling in the upper and lower quantiles are marked (Fig. pairing to low-abundance tRNAs represent slow codons, while those read by abundant tRNA species (Fig.

A water-soluble perylene derivative for live-cell imaging

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Key words: Water-soluble perylene derivative, fluorescence spectrum, absorption spectrum, map calculations, living cell staining.

Antitumor properties of vegetable oil extract from green microalga coelastrella sp.

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Regulation of the cell differentiation, cell cycle and induction of apoptosis were also reported (Niranjana et al., 2015. Li et al., 2015). Our study of the anticancer potential of OE from Coelastrella sp.. Inhibition of the cell proliferation of colon cancer cells by Neochloriso leoabundans carotenoids was observed by Castro-Puyanaet al., (2017).