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Genomic instability

Tìm thấy 13+ kết quả cho từ khóa "Genomic instability"

Estimation of genomic instability and DNA methylation due to aluminum (Al) stress in wheat (Triticum aestivum L.) using iPBS and CRED-iPBS analyses

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However, the role of Al toxicity in interprimer binding site (iPBS) polymorphism, genomic instability, and DNA methylation has not been fully investigated. In the current study, the effects of different Al concentrations on iPBS polymorphism, genomic instability, and DNA methylation were investigated in seedlings of three wheat cultivars: Haymana 79, Kılçıksız, and Bezostaja 1. A higher Al concentration was found to cause DNA methylation.

Genome instability-related long non-coding RNA in clear renal cell carcinoma determined using computational biology

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Results: In the present study, we applied computational biology to identify genome-related long noncoding RNA and identified 26 novel genomic instability-associated lncRNAs in clear cell renal cell carcinoma. To further elucidate the role of the six lncRNAs in the model ’ s genome stability, we performed a gene set variation analysis (GSVA) on the matrix.

Identification of differentially expressed genomic repeats in primary hepatocellular carcinoma and their potential links to biological processes and survival

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The high level of genomic instability reflected by epigenetic events makes the therapy challenging (Fernández-Barrena et al., 2020).

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

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We show that YAP not only correlates with posi- tivity of the genomic instability marker pH2AX in CCA tissues but also that YAP and TAZ cooperate in the regulation of the CIN25 gene signature [18]. For example, inactivation of the serine/threonine kinase LATS1, which directly phosphorylates/inactivates YAP and TAZ, caused CIN and tumor formation [33]..

MethCNA: A database for integrating genomic and epigenomic data in human cancer

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Keywords: Copy number aberration, DNA methylation, Data integration, Cancer, Infinium HumanMethylation450 BeadChip, Genomic data, Epigenomic data. Genomic instability is a hallmark of malignant tumors, causing DNA copy number changes in most cancer types [1, 2]. These copy number aberrations (CNAs) are important influential factors for altered gene expression levels in cancer [3].

Crosstalk between autophagy and DNA repair systems

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Autophagy deficiency caused by Beclin-1 heterozygosity resulted in genomic instability following ROS accumulation and DNA damage to drive breast cancer tumorigenesis (Karantza- Wadsworth et al., 2007).

Landscape of homologous recombination deficiencies in solid tumours: Analyses of two independent genomic datasets

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Kraya et al [40] reported that in BRCA1/2 breast cancers that HRD scores and hormone receptor subtype were predictive of immunogenicity resulting from their increased genomic instability making them theoretically more sensitive to checkpoint inhibitors, although in practice only 20% of patients with BRCA1/2 mutations respond to PD-1/PD-L1 inhibition suggesting that a combination of factors involving BRCA1/2 status, HRD and hormone receptor status may more effectively predict breast cancer patients

Examining the involvement of Slx5 in the apoptotic response to chronic activation of the spindle assembly checkpoint

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However, recent studies suggest that sumo-targeted ubiquitin ligases can prevent or trigger genomic instability depending on the nature of the DNA damage (Nie et al., 2017), and genomic instability may induce apoptosis (Zhivotovsky and Kroemer, 2004).. Although it has been demonstrated that DNA damage accumulates in cells during prolonged mitotic arrest (Hain et al., 2016), not much is known about the nature of the damage.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas:. Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung.

Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3)

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Inactivation of the p53 pathway compromises cell cycle arrest, attenuates apoptosis induced by DNA damage or other stimuli, and predisposes cells to chromosome instability. This genomic instability greatly increases the probability that p53 null cells will acquire additional mutations and become malignant. In summary, it is likely that all human cancers have genetic alterations that inactivate the Rb and p53 tumor-suppressor pathways..

Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks

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We performed strain-level identification, assessed the presence of transferable AMR genes and VF genes, and evaluated the genomic instability of the isolates. Of the seven probiotic products (product number: P2, P3, P4, P5, J6, J7, and F8), bacterial species information was included in their product specification (Table S1), while none of them had bacterial strains information.. Whole genome sequencing.

Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine

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The genealogy of BCG strains is thus further complicated by the genomic instability of the oriC during in vitro culti- vation (Fig. Together, these data underline the importance of the genomic characterization of the BCG vaccine strains, in- cluding their dynamic duplications. Furthermore, they demand for the specification of the exact origin of the BCG strain(s) used in studies on this vaccine and the determination of the presence of the RD documented for that strain.

Long-term health and germline transmission in transgenic cattle following transposonmediated gene transfer

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NGS analysis of the genome of SNU-F1–2 identified six transgene integration sites and no genomic instability (Additional file 6: Table S1 and Additional file 7:. Both SNU-F1–1 and SNU-F1–2 were gener- ated from a single embryo and there was no mosaicism.. As expected, cells from SNU-F1–2 (six copies) showed an approximately 2.2-fold higher expression level of GFP compared to cells from SNU-F1–1 (three copies) (Fig.

Identification of genomic regions regulating sex determination in Atlantic salmon using high density SNP data

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Genomic instability of the sex-determining locus in Atlantic salmon (Salmo salar). Evolution of sex determination loci in Atlantic salmon. Sex chromosome evolution, heterochiasmy and physiological QTL in the salmonid brook charr Salvelinus fontinalis. Comparative a of the shared sex- determination region (SDR) among salmonid fishes. Expansion by whole genome duplication and evolution of the sox gene family in teleost fish..

Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infltration

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instability.

Early postoperative hemodynamic instability after heart transplantation – incidence and metabolic indicators

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Postoperative hemodynamic instability altered the long‑. term outcome and increased 5‑year mortality after HTX (p = 0.034).. Conclusions: Hemodynamic instability is a more common phenomenon than PGD. Only early postoperative serum lactate levels correspond with hemodynamic instability following HTX. Postoperative hemodynamic instability is associated with poor long‑term survival among HTX recipients..

CNVs are associated with genomic architecture in a songbird

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The genomic features enriched in CNVs (homologous regions, masked regions, CpG sites, TSSs and AT-rich intervals) support specific mech- anisms of the formation of CNVs. Therefore, we expect the CNVs identified here to be valuable for future studies on the great tit genome, but the non-random distribution and inheritance patterns of CNVs indicate that they should be inter- preted in the light of their genomic architecture and false negative rate..

A diagnostic tool for people with lumbar instability: A criterion-related validity study

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A total of 140 participants with CLBP were included in the present study. of the 140 participants, 12.86%. had lumbar instability and 87.14% did not. Only the RMDQ was significantly (P = 0.04) higher in the lumbar instability group. Among of the 47 segments, the most commonly recorded levels of instability were L 4-5 (n = 20. 0.05) in participants with lumbar instability. 0.05) in the lumbar instability group..

Management of atraumatic shoulder instability in physiotherapy (MASIP): A survey of physiotherapy practice

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Diagnosis and management of atraumatic shoulder instability. BESS/BOA patient care pathways: atraumatic shoulder instability. Posterior shoulder instability classification, assessment, and management:. Involuntary inferior and multidirectional instability of the shoulder:. The effectiveness of rehabilitation for nonoperative management of shoulder instability: a systematic review.

Genomic variation between PRSV resistant transgenic SunUp and its progenitor cultivar Sunset

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Those ‘Sunset’ or ‘SunUp’ regions where specific norgDNAs are detected could be newly formed via shuf- fling and the rearrangement of extant genomic norgDNA fragments when bombardment-induced ex- ogenous DNA was integrated into the genome causing instability, or new transfer from organelle genomes which was accompanied by bombardment-mediated transformation.