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Human genome

Tìm thấy 20+ kết quả cho từ khóa "Human genome"

Discovering candidate imprinted genes and imprinting control regions in the human genome

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The positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the hu- man genome: https://purr.purdue.edu/publications/3208/1. Density of ZFBS-Morph overlaps in the build hg19 of the human genome:. The positions of the MLL morphemes in the build hg19 of the human genome: https://purr.purdue.edu/publications/1639/1. The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.

Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition

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However, little is known for core promoter diversity in the human genome and its relationship with diseases. We hypothesized that as a functional important component in the genome, the core promoter in the human genome could be under evolutionary selection, as reflected by its highly diversification in order to adjust gene expression for better adaptation to the different environment..

Identification of functional regulatory elements in the human genome using pooled CRISPR screens

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CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Copy number variation in human genomes from three major ethno-linguistic groups in Africa

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Global variation in copy number in the human genome. The clinical context of copy number variation in the human genome. Ethnologue: Languages of the World. The database of genomic variants: a curated collection of structural variation in the human genome. Linkage disequilibrium patterns of the human genome across populations. Population-genetic nature of copy number variations in the human genome. Population structure in copy number variation and SNPs in the CCL4L chemokine gene.

The genome-wide landscape of C:G > T:A polymorphism at the CpG contexts in the human population

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The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. reveal asymmetric cellular dynamics in the early human embryo. Initial sequencing and analysis of the human genome.. CpG mutation rates in the human genome are highly dependent on local GC content. Investigating the relationship of DNA methylation with mutation rate and allele frequency in the human genome. Germline determinants of the somatic mutation landscape in 2,642 cancer genomes.

Circular DNA intermediates in the generation of large human segmental duplications

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Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome. Near-random distribution of chromosome-derived circular DNA in the. Deciphering the code of the Cancer genome:. Patterns of segmental duplication in the human genome. Recent segmental duplications in the human genome

Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral

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More- over, given that we use relative values of substitution rate, this filtering step can be applied to any region of the gen- ome regardless of the amount of functional annotation.. 1 Overlaps between functional regions of the human genome and the evolutionary model. Left, Venn diagram showing percentage of the human genome that overlaps with known non-coding functional annotations and conserved regions of the human genome.

A chromosome-scale assembly of the smallest Dothideomycete genome reveals a unique genome compaction mechanism in filamentous fungi

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By the early twenty-first century, sequencing of the human genome was complete [1]. 1.5% of the total DNA, the human genome was character- ized as a C-value paradox. contrast, the genome of the pufferfish (Fugu rubripes) is one-eighth the size of the human genome but it has a simi- lar gene repertoire, so it was classified as a compact- genome vertebrate [4, 5]. and Taphrina deformans, both of the Taphrinomycotina subphylum, were also recognized to have compact genome structures [7–9]..

Competitive mapping allows for the identification and exclusion of human DNA contamination in ancient faunal genomic datasets

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These sequences could have three origins, 1) true endogenous sequences from regions of the genome highly conserved or identical to the human genome, 2) human contaminant sequences from regions of the genome highly conserved or identical to the target genome, or 3) microbial contaminant se- quences that would align to any mammalian genome by.

Structural variation of the malariaassociated human glycophorin A-B-E region

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Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Capsid region involved in hepatitis a virus binding to glycophorin a of the erythrocyte membrane. The database of genomic variants: a curated collection of structural variation in the human genome

Genome-wide detection of CNV regions and their potential association with growth and fatness traits in Duroc pigs

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Pig genome ( Sus scrofa 11.1), annotations (v103) and the accession numbers listed in Table S6 and Table S7 can be obtained from ENSEMBL (http://ftp.ensembl.org/pub/release-103/).. Structural variation in the human genome.. https://doi.org/10.1038/nrg1767.. https://doi.. org/10.1093/nar/gkt958.. org/10.1038/nrg3871.. https://doi.org/10.1186/s .

Detection of copy number variants in African goats using whole genome sequence data

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A copy number variation map of the human genome. https://doi.. org/10.1038/nrg3871.. https://doi.org/10.1056/. https://doi.org/10.1038/ng.909.. https://doi.org .

Detecting fitness epistasis in recently admixed populations with genome-wide data

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Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region. Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Classification of hypotheses on the advantage of amphimixis.. A map of recent positive selection in the human genome.

Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations

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The pattern has been observed in the human genome [25]. We show our data that the median distance between the nearby tAI- up and tAI-down mutations is less than 90 bp (Add- itional file 1: Figure S7).

Genome-wide detection of CNVs and their association with performance traits in broilers

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Genome-wide patterns of copy number variation in the diversified chicken genomes using next-generation sequencing. A high-resolution survey of deletion polymorphism in the human genome. Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation. Review of quantitative trait loci identified in the chicken.

Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication

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Origins and functional impact of copy number variation in the human genome.. The legacy of domestication: accumulation of deleterious mutations in the dog genome. Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken. A high-resolution map of segmental DNA copy number variation in the mouse genome. Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis.

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

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A map of the cis-regulatory sequences in the mouse genome.. Hoffman MM, et al. Roadmap Epigenomics Consortium, T, et al. Creyghton MP, et al. Kim TH, et al. Transcriptional regulatory elements in the human genome. Sanyal A, et al. Kagey MH, et al. Liu W, et al. Hindorff LA, et al. Maurano MT, et al. Hnisz D, et al. Super-enhancers in the control of cell identity and disease.. Ring N, et al. Dickel DE, et al. Li Y, et al. Seruggia D, et al. Dao LTM, et al. Canver MC, et al. Cunningham TJ, et al.

How it works book of the human body

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This copy contains all of the information required to make a protein – the building blocks of the human body.. One of our closest living relatives – the solid bands demonstrate we share a great deal of genetic information (ie 98 per cent).. Completion of the Human Genome Project. One such trait is albinism – the absence of pigment in the skin, hair and eyes due to a defect in the protein that makes melanin..

Chromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome

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A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat. De novo assembly of the Aedes aegypti genome using hi-C yields chromosome-length scaffolds.

Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs

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A copy number variation map of the human genome. The importance of the type I interferon system in autoimmunity. Exacerbation of thyroid autoimmunity by interferon alpha treatment in patients with chronic viral hepatitis: our studies and review of the literature. An integrated encyclopedia of DNA elements in the human genome. Resolving the complexity of the human genome using single-molecule sequencing.