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Chủ đề : Antimicrobial resistance


Có 11+ tài liệu thuộc chủ đề "Antimicrobial resistance"

Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks

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Whole-genome analysis of probiotic. Background: Safety issues of probiotic products have been reported frequently in recent years. Ten bacterial strains isolated from seven commercial probiotic products on market were evaluated for their safety, by whole-genome analysis.. Results: We found that the bacterial species of three probiotic products were incorrectly labeled. Conclusions: Our work clearly illustrates that whole-genome analysis is a...

ACEP: Improving antimicrobial peptides recognition through automatic feature fusion and amino acid embedding

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Results show that the proposed model outperforms state-of-the-art methods on recognition of AMPs. By visualizing data in some layers of the model, we overcome the black-box nature of deep learning, explain the working mechanism of the model, and find some import motifs in sequences.. Full list of author information is available at the end of the article. 2020 Open Access...

Global transcriptomic responses orchestrate difenoconazole resistance in Penicillium spp. causing blue mold of stored apple fruit

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Background: Blue mold is a globally important and economically impactful postharvest disease of apples caused by multiple Penicillium spp . Active efflux pumps were coordinately regulated in the resistant isolate and were shown to mediate the global resistance response as their inhibition reversed the difenoconazole-resistant phenotype in vitro.. Conclusions: Our data support the observation that global transcriptional changes modulate difenoconazole...

Sequencing of five poultry strains elucidates phylogenetic relationships and divergence in virulence genes in Morganella morganii

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elucidates phylogenetic relationships and divergence in virulence genes in. Additionally, we sequenced the genomes of these strains by NGS and analyzed phylogenetic clustering, resistance and virulence genes in the context of host-specificity.. A comparative genomics analysis of virulence genes showed acquisition of novel virulence genes involved in secretion system and adherence in cluster M2. morganii and an attempt to generate...

TetR-family transcription factors in Gramnegative bacteria: Conservation, variation and implications for efflux-mediated antimicrobial resistance

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Our classical view of TFTRs as simple, single-target regulators therefore needs to be reconsidered. aeruginosa) were then searched for the presence of the TFTRs conserved in Escherichia and Salmonella.. 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0. 1) and it is be- lieved that the majority of TFTRs regulate...

Analysis of isolates from Bangladesh highlights multiple ways to carry resistance genes in Salmonella Typhi

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Although reports suggest a recent reduction in multidrug resistance (MDR) in the Indian subcontinent, the corresponding genomic changes in the background are unknown.. 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0. 2 Laboratório Nacional de Computação Científica, Petrópolis, Brazil Full list of author information is available at the end...

Gen2Epi: An automated whole-genome sequencing pipeline for linking full genomes to antimicrobial susceptibility and molecular epidemiological data in Neisseria gonorrhoeae

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genomes to antimicrobial susceptibility and molecular epidemiological data in Neisseria gonorrhoeae. Background: Recent adva1nces in whole genome sequencing (WGS) based technologies have facilitated multi-step applications for predicting antimicrobial resistance (AMR) and investigating the molecular epidemiology of Neisseria gonorrhoeae. Results: We present Gen2Epi, a pipeline that assembles short reads into full scaffolds and automatically assigns molecular epidemiological and AMR information to...

Whole genome sequence based capsular typing and antimicrobial resistance prediction of Group B streptococcal isolates from colonized pregnant women in Nigeria

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Whole genome sequence based capsular typing and antimicrobial resistance. prediction of Group B streptococcal isolates from colonized pregnant women in Nigeria. Background: Streptococcus agalactiae (Group B Streptococcus, GBS) is one of the major bacterial pathogens responsible for neonatal sepsis. Whole genome sequencing has, in recent years, emerged as a reliable tool for capsular typing and antimicrobial resistance prediction. This study...

Whole genome sequencing analysis of multiple Salmonella serovars provides insights into phylogenetic relatedness, antimicrobial resistance, and virulence markers across humans, food animals and agriculture environmental sources

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AMR and virulence genes clustered with the Salmonella serovars, while there were also associations between the presence of virulence genes in both animal/environmental isolates and human clinical samples.. Full list of author information is available at the end of the article. 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0....

Review on antimicrobial peptides from Malaysian amphibian resources: status, research approaches and ways forward

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Conlon et al., 2019). These organisms include plants, microorganisms, humans, and animals (König et al., 2015;. Dahham et al., 2016. Chai et al., 2019. Conlon et al., 2019).. The first AMPs isolated and fully revealed from an animal were cecropins isolated from the Native American moth (Hyalophora cecropia) (Steiner et al., 1981). al., 2006. Pasupuleti et al., 2011). Most AMPs ...