Có 10+ tài liệu thuộc chủ đề "Photodynamic therapy"
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photodynamic therapy in cancer cell lines of different origin. Results: Here, we report that photodynamic treatment of tumor cell lines of different origin in combination with Alectinib increased protoporphyrin-IX specific fluorescence and concomitantly cell death.. The aim of this study was to find out whether pre- treatment of tumor cells with Alectinib leads to an en- hanced concentration of PpIX...
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Investigation of the photophysical and photochemical behavior of substituted zinc phthalocyanines and their water-soluble quaternized derivatives. All studied zinc(II) phthalocyanine complexes generated high singlet oxygen, especially in dimethylsulfoxide, and these properties make them potential photosensitizers for use in the photodynamic therapy of cancer. The effects of the position and quaternization of the substituents on the photophysical and photochemical properties were...
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An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic. Abstract: A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here.. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the...
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doi:10.3906/kim-1909-32 h t t p. To determine the photody- namic therapy potential of compound 4, singlet oxygen quantum yield, DNA binding and cleavage, and topoisomerase I inhibition experiments were performed. The singlet oxygen quantum yield value of compound 4 was found higher than that of the standard unsubstituted zinc(II) phthalocyanine compound (Std-ZnPc). pBR322 plasmid DNA cleavage activity of the compound...
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doi:10.3906/kim-1902-57 h t t p. Entrapment of organic fluorophores in calcium phosphate nanoparticles with slow release. Abstract: Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Key words: Calcium phosphate nanoparticles, slow release, entrapment, organic fluorophores. Within this context, calcium phosphate nanoparticles...
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Synthesis and effect of substituent position, metal type on the electrochemical properties of (3-morpholin-4-ylpropoxy) groups substituted cobalt, manganese. Electrochemical studies show that (3-morpholin-4-ylpropoxy) group substituted Co(II)Pc and Mn(III)Pcs electropolymerized on the Pt working electrode.. On the other hand, electrochemical characterization of phthalocyanines is important for the electrocatalyst [13], electrosensing [14], electropolymerization [15,16], electrochromic fields [17].. In this work, we have...
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doi:10.3906/kim-2008-48. Electrochemical properties of phthalocyanines in the electrolytic solution, are dependent ontheir energy values of the HOMOs and LUMOs of the frontier orbitals [15]. Electrochemical properties of the proposed compounds may have the possible potential usage in electrocatalysis, electrosensing, and electrochromic devices. The optimized molecular structure and gauge-including atomic orbital (GIAO) 1 H and 13 C NMR chemical shift values...
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Abstract: The recent advances in the synthesis of carborane and boronic ester-substituted tetrapyrroles (porphyrins, porphyrazines, and phthalocyanines) are reviewed together with their possible utilization as agents for photodynamic therapy (PDT) and boron neutron capture therapy of cancer (BNCT) as well as dual PDT/BNCT sensitizers.. The basic tetrapyrrole skeleton of porphyrin, found in many natural pigments, is probably one of the...
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singlet oxygen formation ( Φ. and photodegradation ( Φ d ) for the zinc phthalocyanine were found to be and respectively. The photophysicochemical properties of the phthalocyanines (2 and 3) clearly reveal that these phthalocyanines could be used in singlet oxygen applications such as photodynamic therapy.. Inserting substituents into the peripheral positions of the macrocycles enhances their solubility since these...
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Antiinflammatory photodynamic therapy potential of polyoxyethylene-substituted perylene diimide, nitrocatechol, and azo dye. The polyoxyethylene side chain increases the polarity and solubility of the molecule. Perylene-3,4,9,10-tetracarboxylic diimide derivatives containing a π-conjugated system with a perylene aromatic core have gathered a substantial interest in the field as fluorophores. Both symmetrical and unsymmetrical perylene diimides (PDIs) have been chemically and photodynamically stable, are...