Có 10+ tài liệu thuộc chủ đề "Extracellular matrix"
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One member of the 12-lncRNA signature was experimentally supported by siRNA knockdown, which resulted in attenuated differentiation of quiescent fibroblasts to a cancer-associated phenotype.. 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0. 7 Almac Diagnostic Services, Craigavon, Northern Ireland, UK Full list of author information is available at the...
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Transcriptional characterisation of the Exaiptasia pallida pedal disc. This study had two aims: 1) To characterise tissue-specific gene regulation in the pedal disc of the model cnidarian Exaiptasia pallida, and 2) to elucidate putative genes involved in pedal disc adhesion.. Results: Five hundred and forty-seven genes were differentially expressed in the pedal disc compared to the rest of the animal....
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The transcriptome landscape of the. carcinogenic treatment response in the blind mole rat: insights into cancer. Conclusion: The comparison of the treated with the untreated tissue revealed a regulatory complex that might give an answer how Spalax is able to restrict the tumor growth. regulatory cluster plays a major role in the cancer resistance of Spalax. 2019 Open Access This...
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domains 1 (CSMD1) expression by miRNA- 190a-3p enhances hypertrophic scar-. The knockdown of CSMD1 resulted in enhanced migration and fibronectin1 (FN1) secretion in fibroblasts in vitro. The screening of four common microRNA (miRNA) databases suggested that miR-190a-3p binds to the CSMD1 and may regulate its expression. We confirmed that miR-190a-3p directly targeted the CSMD1 – 3 ′ -UTR using luciferase...
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Opposite effects of the triple target (DNA- PK/PI3K/mTOR) inhibitor PI-103 on the. Results: We found that PI-103 radiosensitized MO59K cells but, surprisingly, it induced radiation resistance in MO59J cells. Treatment of MO59K cells with PI-103 lead to protraction of the DNA damage repair as compared to drug-free irradiated cells. In PI-103-treated and irradiated MO59J cells the foci numbers of both...
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Longitudinal serological assessment of type VI collagen turnover is related to progression in a real-world cohort of idiopathic pulmonary fibrosis. Background: Remodeling of the extracellular matrix (ECM) is a central mechanism in the progression of idiopathic pulmonary fibrosis (IPF), and remodeling of type VI collagen has been suggested to be associated with disease pro- gression. Methods: Two serological biomarkers reflecting...
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A decellularization strategy composed of TriseHCl and Sodium Dodecyl Sulfate was developed for adipose tissue. The AAM powder was prepared by mechanical disruption under reduced temperatures, which resulted in an AAM particle size in the range of 100 m m. In the following 8 week post-injection period, AAM supported the in vivo adipogenesis observed in the peripheral side along the...