Có 20+ tài liệu thuộc chủ đề "Head and neck cancer"
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Hence, we aim to perform a systematic literature search following PRISMA guidelines to study AS events in HNC identified through RNA-Seq studies.. Results: A total of five records were identified that utilized RNA-Seq data for identifying AS events in HNC. Five software was used in these records to identify AS events. Alternative splicing (AS) is a key molecular mechanism through...
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Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by. Recent studies have also revealed that the expression of DFNA5 is suppressed in many cancer types. however, little is known about the function of DFNA5 in head and neck squamous cell carcinoma (HNSCC). Accordingly, the aim of the present study was to evaluate the expression of DFNA5...
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Head and neck cancer risk factors in the French West Indies. Little is known about other risk factors in the FWI. We assessed associations between several factors and HNSCC risk, their population attributable fractions (PAF) in the FWI, and compared these PAFs by subsite, sex and age.. Prevention programs for HNSCC in the FWI should target tobacco and alcohol cessation,...
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Cell-free DNA and circulating tumor cell kinetics in a pre-clinical head and neck Cancer model undergoing radiation therapy. While liquid biopsies maintain significant promising benefits, there is still limited information regarding the kinetics of ctDNA and CTCs following radiation therapy which remains a vital treatment modality in head and neck cancers. Methods: Seven rabbits were inoculated with VX2 cells in...
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Association of neutrophil-to-lymphocyte ratio with severe radiation-induced. mucositis in pharyngeal or laryngeal cancer patients: a retrospective study. Radiotherapy for head and neck cancer leads to mucositis in almost all patients and severe radiation-mucositis affects their quality of life (QOL).. Methods: In this retrospective study, we determined the incidence of grade 3 mucositis in 99 patients who were receiving definitive radiotherapy...
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Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta- analysis. Background: Head and Neck Cancer (HNC) survivors are at increased risk of developing a second primary cancer (SPC). Quality of the included studies was assessed using the Q-Genie tool.. Keywords: Head and neck cancer, Second...
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advanced head and neck cancer: results of a national survey among radiation. Background: Nutritional complications in patients with locally advanced head and neck cancer (LA-HNC) treated by concurrent chemoradiotherapy (CCRT) often lead to placement of a prophylactic gastrostomy (PG) tube, while indication lacks harmonization. Twenty three treat more than 20 head and neck (HNC) patients per year, while four (1...
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Changes in carnitine levels through. induction chemotherapy in head and neck cancer patients as a potential cause of. Methods: This single-center prospective study investigated 20 patients diagnosed with primary head and neck cancer who underwent IC with cisplatin, docetaxel, and 5-fluorouracil. Keywords: Carnitine, Free carnitine, Induction chemotherapy, Head and neck cancer, Cisplatin. 36 μ M/mL in the Guidelines for Diagnosis...
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Adenoid cystic Carcinoma and Carbon ion Only irradiation (ACCO): Study protocol for a prospective, open, randomized, two-. Background: Adenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for local tumor control. There is a paucity of randomized clinical data examining the role of the use of...
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This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance immunohistochemical screening of potential immunohistochemical biomarkers for radioresistance in HNSCC cell lines.. Methods: Twenty-nine HNSCC cell lines were cultured, cell pellets formalin-fixed, paraffin-embedded, and arrayed.. Radioresistance features of the cell lines were combined to immunohistochemical stains for p53, NDFIP1, EGFR, stem cell marker Oct4, and PP2A inhibitor...
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Resilience and its associated factors in head and neck cancer patients in Pakistan: an. Introduction: The study aimed to assess resilience and its associated factors in head and neck cancer patients, post-treatment in a low middle income country (LMIC) such as Pakistan.. Methods: An analytical cross-sectional study was conducted from November 2019 to May 2020 among head and neck cancer...
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Pre-existing interstitial lung disease is associated with onset of nivolumab-. induced pneumonitis in patients with solid tumors: a retrospective analysis. The aim of this study was to examine the association between pre-existing interstitial lung disease (ILD) on chest computed tomography (CT) and nivolumab-induced pneumonitis among different types of solid tumors.. We collected baseline patient characteristics and assessed pre-existing ILD on...
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It is composed of cancer- related structures in the head and neck, including the lips, mouth, nasal cavity, paranasal sinuses, salivary glands, oropharynx, nasopharynx, hypopharynx, and larynx (Jemal et al., 2007). The mortality rate is 0.53, and death is three times more frequent in men (Pehlivan et al., 2008).. metastasis is still the main cause of death in HNC patients...
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a cross-sectional study of 505 post-treatment head and neck cancer survivors. Background: Studies suggest a high prevalence of pain in head and neck cancer (HNC) patients at diagnosis, during and after treatment. We surveyed a large cohort of HNC survivors to determine variations in the prevalence of pain, its treatment and management by duration of survivorship, and assessed a comprehensive...
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changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer. This prospective study evalu- ates dynamic changes in cfHPV-DNA during induction therapy, definitive (chemo)radiotherapy, and post-treatment surveillance in the context of risk and response-adaptive treatment for HPV + OPC.. Methods: Patients with locoregional HPV + OPC are stratified into two cohorts: High risk (HR) (T4, N3. 50% response receive treatment...
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Head and Neck Cancer (Part 1). Head and Neck Cancer. Head and Neck Cancer: Introduction. Epithelial carcinomas of the head and neck arise from the mucosal surfaces in the head and neck area and typically are squamous cell in origin. Tumors of the salivary glands differ from the more common carcinomas of the head and neck in etiology, histopathology, clinical...
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Head and Neck Cancer (Part 2). The manifestations vary according to the stage and primary site of the tumor. Cancer of the nasopharynx typically does not cause early symptoms.. However, on occasion it may cause unilateral serous otitis media due to obstruction of the eustachian tube, unilateral or bilateral nasal obstruction, or epistaxis. Advanced nasopharyngeal carcinoma causes neuropathies of the...
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Head and Neck Cancer (Part 3). Table 84-1 TNM Classification for Head and Neck Cancer (Except Nasopharyngeal). T1 0–2 cm 0–2 cm. T2 2.1–4 cm >1 site, 2–4 cm. T3 >4 cm >4 cm. T4b Lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery invasion. Invasion of prevertebral fascia, encases carotid artery, or involves mediastinal...
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Head and Neck Cancer (Part 4). TX Cannot be. Tis N0 M0. T1 N0 M0. T2a N0 M0. T1 Tumor confined to the nasopharynx. T1 N1 M0. T2 Tumor extends to soft tissues. T2 N1 M0. extends to the oropharynx and/or nasal. parapharyngeal extension. T2a N1 M0. T2b Any tumor with parapharyngeal extension. T2b N1 M0. T3 Tumor involves bony...
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Patients with head and neck cancer can be categorized into three clinical groups: those with localized disease, those with locally or regionally advanced disease, and those with recurrent and/or metastatic disease. These lesions are treated with curative intent by surgery or radiation therapy. Radiation therapy is often preferred for laryngeal cancer to preserve voice function, and surgery is preferred for...