Có 40+ tài liệu thuộc chủ đề "Journal of Biology"
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doi:10.3906/biy-1908-10. In vitro study on chondrogenic differentiation of human adipose-derived stem cells on treated bovine pericardium. Augmentation rhinoplasty is known as a procedure in plastic surgery in which autogenous tissues or implants are inserted into the patient’s nose structure to correct physical problems (e.g., congenital disabilities, trauma, infection, excessive reduction rhinoplasty, or submucosal resection) (Nguyen et al., 2015) or purely...
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In silico approach to the analysis of SNPs in the human APAF1 gene. The disruption of the apoptosis process can lead to human diseases such as cancer, neurodegenerative disorders, heart disease, autoimmunity, and immunodeficiencies (Ferraro et al., 2003). Apoptosis protease-activating factor 1 (APAF1) has a crucial function in apoptosis (Bao et al., 2007). APAF1 is the molecular core of the...
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Many terpenes are defined as harmful chemicals having prooxidant, cytotoxic, genotoxic, and neurotoxic effects (Chueca et al., 2014. Sharma et al., 2019), whereas some other studies (Bastaki et al., 2018;. Camphor (1,7,7-trimethylbicyclo[2.2.1]heptan-2-one), which is classified among the bicyclic monoterpenes constituted of 2 isoprene units and 10 carbon atoms, is a white-colored powder and found in the camphor tree and other...
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Members of this genus are known to enhance plant growth (Sousa et al., 2008. Sathya et al., 2017). Jus showed positive results for IAA acid production, phosphate solubility, and siderophore production and it was determined that these isolates had high performance in the development of tomato (Verma et al., 2011). A Streptomyces isolate was proven to be useful under salt...
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Citrillus lanatus (watermelon) is an important plant in the family Cucurbitaceae, constituting 7% of the world’s total fields devoted to crop production. Perkins-Veazie et al., 2006. Collins et al., 2007. Guo et al., 2013).. Kumar et al., 2012. Hsps are functional in many processes such as protein folding, cellular regulation, and inhibition of the accumulation of inappropriate proteins in the...
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B lymphocytes differentiate into plasma cells which secrete antibodies against specific antigens displayed on pathogens (Slifka et al., 1998). Vivier et al., 2008). The World Health Organization classifies HLs into two main categories: nodular lymphocyte predominant HL and classical Hodgkin’s lymphoma (cHL) (Swerdlow et al., 2016). STAT3, STAT5B, JAK1, JAK2, and PTPN1) in 87% of cHL cases (Tiacci et al.,...
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Doxorubicin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells, opposite to its effects on MDA-MB-231 cells. PD-L1 expression in multiple solid tumors, including CRC, was shown to be associated with worse survival (Wu et al., 2015). Here, we investigated the changes in the expression of PD-L1 in DOX-treated CRC and breast cancer (BRC) cells. HCT116 CRC and MDA-MB-231...
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Hepatocellular carcinoma (HCC) is one of the most common types of cancer that originates from hepatocytes.. For approximately 70% of patients with HCC, this period is about 5 years (Wang et al., 2012). Treatment of the disease depends on tumor size and stage, and high-grade tumors result in poor prognosis. Surgery is one of the main treatment methods for HCC....
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Vascular endothelial growth factor (VEGF) or vascular permeability factor (VPF) (Senger et al., 1983. Nowak et al., 2010). VEGF is a heparin-binding growth factor (Leung et al., 1989) and an effective mitogen for endothelial cells (Walsh et al., 2002). Taktak-Ben Amar et al., 2017), among which 2 cysteine residues contribute to. homodimer structure and the other six generate three- loop...
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Acute renal ischemia-reperfusion (I/R) injury can be described as the damage occurring in ischemic renal cells after the reestablishment of the blood supply (Gao et al., 2018). Acute renal I/R injury is one of the pathological mechanisms underlying acute renal failure and is likely to occur following renal transplantation and septic shock (Gao et al., 2018). Zou et al., 2013)....
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doi:10.3906/biy-2002-12. Proximity mapping of the microtubule plus-end tracking protein SLAIN2 using the BioID approach. The centrosome is the main microtubule-organizing center of animal cells, which play skey roles in critical cellular processes ranging from cell division to cellular signaling (Chavali et al., 2014). Mirvis et al., 2018). Centrosome and cilium dysfunction are associated with a variety of human diseases including...
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Transcriptional splice variants of CD40 and its prognostic value in breast cancer. It is expressed on the surface of B cells, macrophages,and dendritic cells, as well as in various cancer cell lines and tissues including non-small cell lung cancer, ovarian, urinary bladder cancer, breast melanoma, pancreatic cancer, colon cancer, and B-lineage malignancies (Ara et al., 2018. Argiriadi et al., 2019....
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Influenza A viruses are members of the family Orthomyxoviridae, which includes enveloped and segmented negative-sense single-stranded RNA (ssRNA–) viruses. The viral genome consists of 8 ssRNA molecules (Eisfeld et al., 2015. McGeoch et al., 1976). Each individual viral RNA (vRNA) is associated with the nucleoprotein (NP) as a viral ribonucleoprotein (vRNP) particle (Eisfeld et al., 2015. Honda et al., 1988....
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Type 2 diabetes (T2D) is a chronic disease that affects millions of people around the world negatively and causes various micro- and macrovascular complications in the body (Drong et al., 2012). In recent years, the prevalence of T2D in developed and developing countries has increased drastically, making the disease one of the most important threats to public health (Whiting et...
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MSAP analysis reveals diverse epigenetic statuses in opium poppy varieties with different benzyisoquinoline alkaloid content. Papaver somniferum L., commonly known as opium poppy, is one of the most important medicinal plants due to its valuable benzyisoquinoline alkaloids (BIA). Today, opium poppy still remains the only commercial source of morphinan alkaloids. Due to these unique features, the genome sequence of the...
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For this purpose, genome editing technologies were developed (Memi et al., 2018). Hirch et al., 2019). Roh et al., 2018). This allows researchers to modify the genome in practice in any region (Memi et al., 2018).. The creation of changes in the genome depends mainly on the DNA repair capacity of the cells (Lau et al., 2018).. CRISPR-Cas9 is a...
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The regulation of the nutrient balance in the human body is strictly regulated, especially in the central nervous system (CNS). Effective maintenance of the CNS is mediated by a specific barrier, called the blood–brain barrier (BBB), which restricts the permeability of some molecules, as well as nutrients from the blood, to the CNS. On the other hand, the selectivity of...
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Nanotechnology-based delivery vehicles, such as nanoparticles, nanocapsules, micelles, or dendrimers, have great potential to be utilized in nanomedicine to deliver conventional drugs, recombinant proteins, vaccines, and more recently genetic material, by addressing the problems related to poor solubility, high toxicity, nonspecific delivery, in vivo degradation, and short circulation half-lives of conventional drugs, which often limits optimal dosage at the target...
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Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro. Breast cancer is abnormal cell proliferation in the ductal and gland regions of the breast tissue. The estimated number of breast cancer patients and deaths by the end of 2020 in the United States will be approximately 279,100 and 42,690 respectively (Siegel et al., 2020). Treatment options for breast cancer are...
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AKT-mediated phosphorylation of TWIST1 is essential for breast cancer cell metastasis. Howard et al., 1997. el Ghouzzi et al., 1997. Qin et al., 2012). Studies related to this have shown that TWIST1 inhibits ossification by inhibiting the activities of RUNX2 and MyoD1, which are responsible for osteogenic and myogenic differentiation, respectively (Rice et al., 2000;. Bialek et al., 2004. Connerney...